Elucidation of pathogenic mechanism of schizophrenia focused on intracellular signaling by quantitative proteomics

Research Project

Project/Area Number	26860057
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pharmacology in pharmacy
Research Institution	Kumamoto University
Principal Investigator	Hirayama Mio 熊本大学, その他の研究科, 助教 (90706483)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords	プロテオミクス / ネットワーク解析 / 統合失調症 / プロテオーム解析
Outline of Final Research Achievements	We identified differentially expressed proteins in the brains of schizophrenia patients by high-precision quantitative mass spectrometric analysis. A network analysis based on protein-expression data identified a decrease in “GNA13-ERK-eIF4G2” signaling. A co-expression analysis using the protein expression levels determined by targeted proteomics was performed, whereby the signaling proteins significantly correlated between upstream and downstream proteins. These results suggest a correlation between attenuation of the molecular network involving ERK1 in the prefrontal cortex of schizophrenia patients and schizophrenia pathology.

Report

(3 results)