Elucidation of pathogenic mechanism of schizophrenia focused on intracellular signaling by quantitative proteomics
Project/Area Number |
26860057
|
Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Pharmacology in pharmacy
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Research Institution | Kumamoto University |
Principal Investigator |
Hirayama Mio 熊本大学, その他の研究科, 助教 (90706483)
|
Project Period (FY) |
2014-04-01 – 2016-03-31
|
Project Status |
Completed (Fiscal Year 2015)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | プロテオミクス / ネットワーク解析 / 統合失調症 / プロテオーム解析 |
Outline of Final Research Achievements |
We identified differentially expressed proteins in the brains of schizophrenia patients by high-precision quantitative mass spectrometric analysis. A network analysis based on protein-expression data identified a decrease in “GNA13-ERK-eIF4G2” signaling. A co-expression analysis using the protein expression levels determined by targeted proteomics was performed, whereby the signaling proteins significantly correlated between upstream and downstream proteins. These results suggest a correlation between attenuation of the molecular network involving ERK1 in the prefrontal cortex of schizophrenia patients and schizophrenia pathology.
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Report
(3 results)
Research Products
(3 results)