Elucidation of sensors of pulsatile pressure stress in vascular smooth muscle cells and the modulation of cell function by docosahexaenoic acid
| Project/Area Number |
26860061
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pharmacology in pharmacy
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| Research Institution | Health Sciences University of Hokkaido |
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Principal Investigator |
Machida Takuji 北海道医療大学, 薬学部, 准教授 (90433424)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ドコサヘキサエン酸 / 圧力ストレス / 血管平滑筋細胞 / focal adhesion kinase / 細胞増殖 / レゾルビンD1 |
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| Outline of Final Research Achievements |
We have investigated the effects of pressure stress and docosahexaenoic acid (DHA) on vascular smooth muscle cells (VSMCs) function. The pressure stress which simulates systolic hypertension activated focal adhesion kinase in VSMCs. Although we assume that PPAR activation plays a part in the mechanisms of the modulation of cell function by DHA, further studies are required to clarify the precise mechanisms. DHA and resolvin D1 inhibited angiotensin II-induced cell proliferation in the absence or the presence of pressure stress.
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Report
(3 results)
Research Products
(6 results)
