| Project/Area Number |
26860067
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ユビキチン活性化酵素 (E1) / ユビキチン－プロテアソームシステム / 天然低分子化合物 / 抗がん剤 / ユビキチン-プロテアソームシステム / ユビキチン活性化酵素（Ｅ１） / ユビキチンープロテアソームシステム / 海洋無脊椎動物 |
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| Outline of Final Research Achievements |
We have been searching for natural products, which inhibit the ubiquitin-proteasome system, as drug leads for treatment of cancer. In this project, we studied on the inhibitors of the ubiquitin-activating enzyme (E1). We prepared several derivatives of hyrtioreticulin A, which was isolated from the marine sponge as the E1 inhibitor by us, and examined the inhibitory activities of E1. Furthermore, we studied the biosynthetic pathway of the E1 inhibitor, himeic acid A, which was isolated from the fungus Aspergillus sp. isolated from the mussel by us.
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