| Project/Area Number |
26860068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Tohoku Medical and Pharmaceutical University |
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Principal Investigator |
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| Research Collaborator |
BATKHUU Javzan モンゴル国立大学, 応用科学研究科, 教授
DAVAAPUREV Bekh-Ochir モンゴル国立大学, 応用科学研究科, 講師
ODONTUYA Gendaram モンゴル科学アカデミー, 化学工学部門, 主任研究員
SELENGE Erdenechimeg モンゴル薬科学大学, 講師
ISHIKAWA Yoshinobu 静岡県立大学, 薬学研究院, 准教授 (00305004)
UMEHARA Kaoru 静岡県立大学, 薬学研究院, 准教授 (40185070)
SUGANUMA Keisuke 帯広畜産大学, グローバルアグロメディシン研究センター, 特任助教 (60772184)
SASAKI Kenroh 東北医科薬科大学, 薬学部, 教授 (90244970)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | モンゴル国 / 国際情報交換 / 伝統医学 / 薬用植物 / 薬効成分 / 化学構造解析 / 昆虫 / 生物活性試験 |
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| Outline of Final Research Achievements |
Traditional medicines based on natural plants have been used to treat various diseases in Mongolia. Many of them are known as having unique traditions for inflammatory and infectious diseases, and some of them were selected to find pharmaceutical seeds in this project. After the active guided isolations of compounds from Mongolian plants, the purified compound structures including absolute configuration were determined by spectroscopic methods. Then the compounds inhibitory activities against various enzymes, bacteria, protozoa, and insects were evaluated. Pea aphid was used as a model of living organisms, and assay methods were developed using insect immune system which similar to human innate immune system. Phenoloxidase is a component of the insect immune system, and its inhibitors were identified from Atraphaxis frutescens. Furthermore, Trypanocidal new oxazoles, anti- bacterial diterpenoid, and anti-insect acetylcholinesterase phenylpropanoid were isolated from Mongolian plants.
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