| Project/Area Number |
26860074
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Natural medicines
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| Research Institution | Fukuyama University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 不斉認識 / エピガロカテキン-3-O-ガレート（EGCg） / X線結晶構造解析 / NMR / ジケトピペラジン / プロプラノロール |
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| Outline of Final Research Achievements |
Enantiomer, which is relationship between the right hand and the left hand, is known to be difficult to discern and separate them because physical properties are the same. In our previous study, it have been revealed that the tea major compound (-)-epigallocatechin-3-O-gallate (EGCg) captures many substances including caffeine. These results led to the idea that EGCg may be available as a new optical resolving agent for natural products and medicines. Chiral recognition of EGCg is investigated using diketopiperazine cyclo(L-Pro-Gly), cyclo(D-Pro-Gly) and sympathetic β-receptor blocker (R)-propranolol, (S)-propranolol, and we reveal that EGCg can discern these enantiomers.
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