Development of G-quadruplex stabilizing agent for growth inhibition of cancer stem cells
| Project/Area Number |
26860077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Saitama University |
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Principal Investigator |
IIDA Keisuke 埼玉大学, 理工学研究科, 研究支援者 (70719773)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん幹細胞 / グアニン四重鎖 / ケミカルバイオロジー / G4リガンド |
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| Outline of Final Research Achievements |
Cancer stem cells (CSCs) are thought to contribute to tumor recurrence and metastasis in many cancers. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour CSCs behind, which might be an important mechanism of resistance. Therefore, effective drug against CSCs are important for cancer therapy. Recently, stabilization of G-quadruplex, non-nanonical DNA structure, is considered to exerts an antitumor activity.
In this project, we described effect of G-quadruplex stabilizing small molecules (G4 ligands) for CSCs. With G4 ligands, we found a growth inhibitory activity against CSCs through DNA damage responce in vitro. And antitumor activities were also abserved in vivo.
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Report
(3 results)
Research Products
(39 results)
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[Journal Article] Time-resolved crystal structures of the reaction intermediate of nitrile hydrase reveal a role for the cystein-sulfenic acid ligand as a catalyst nucleophile2015
Author(s)
Yasuaki Yamanaka, Yuki Kato, Koichi Hashimoto, Keisuke Iida, Kazuo Nagasawa, Hiroshi Nakayama, Naoshi Dohmae, Keiichi Noguchi, Takumi Noguchi, Masafumi Yohda, and Masafumi Odaka
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Journal Title
Angew. Chem., Int. Ed.
Volume: 54
Issue: 37
Pages: 10763-10767
DOI
Related Report
Peer Reviewed
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[Journal Article] Rif1 binds to G-quadruplexes and suppresses replication over long distances.2015
Author(s)
Yutaka Kanoh, Seiji Matsumoto, Rino Fukatsu, Naoko Kakusho, Nobuaki Kono, Claire Renard-Guillet, Koji Masuda, Keisuke Iida, Kazuo Nagasawa, Katsuhiko Shirahige, and *Hisao Masai
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Journal Title
Nature Struct. Mol. Biol.
Volume: 22
Issue: 11
Pages: 889-897
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Presentation] Interaction with G-quadruplex structures forms a basis for Rif1-mediated regulation of DNA replication, transcription and chromatin architecture2015
Author(s)
Hisao Masai, Yutaka Kanoh, Seiji Matsumoto, Naoko Kakusho, Rino Fukatsu, Kenji Moriyama, Nobuaki Kono, Keisuke Iida, Kazuo Nagasawa, Koji Masuda, Claire Renard-Guillet, Katsuhiko Shirahige, Satoshi Yamasaki, Naoko Yoshizawa
Organizer
BMB2015（第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会）
Place of Presentation
神戸ポートアイランド (兵庫県 神戸市)
Year and Date
2015-12-01
Related Report
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