| Project/Area Number |
26860077
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Saitama University |
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Principal Investigator |
IIDA Keisuke 埼玉大学, 理工学研究科, 研究支援者 (70719773)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | がん幹細胞 / グアニン四重鎖 / ケミカルバイオロジー / G4リガンド |
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| Outline of Final Research Achievements |
Cancer stem cells (CSCs) are thought to contribute to tumor recurrence and metastasis in many cancers. Although chemotherapy kills most cells in a tumour, it is believed to leave tumour CSCs behind, which might be an important mechanism of resistance. Therefore, effective drug against CSCs are important for cancer therapy. Recently, stabilization of G-quadruplex, non-nanonical DNA structure, is considered to exerts an antitumor activity.
In this project, we described effect of G-quadruplex stabilizing small molecules (G4 ligands) for CSCs. With G4 ligands, we found a growth inhibitory activity against CSCs through DNA damage responce in vitro. And antitumor activities were also abserved in vivo.
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