| Project/Area Number |
26860082
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Shujitsu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 医薬品探索 / 非ステロイド性抗炎症薬 / 非ステロイド系抗炎症薬 |
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| Outline of Final Research Achievements |
The present study aimed at the elucidation of a relationship between a gene induced by NSAIDs-depend and pharmacological action, and at the synthesis and evaluation of a clinically useful compounds by using organic synthetic technique. Particularly, these trials could be useful to develop of pharmaceutical compounds having more effective and high-safety as drug by analyzing the molecular mechanism in conjunction with the side effect in detail. In this study, we have clarified that the compounds which is high-selectivity to the cyclooxygenase have high membrane permeability than non-selectivity compounds.
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