Molecular basis of the starvation response of novel intestinal organelles in C. elegans
| Project/Area Number |
26860087
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Iwate Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | 遺伝学 / 栄養シグナル / オルガネラ / 線虫 / 飢餓 / シグナル伝達 |
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| Outline of Final Research Achievements |
The intestinal cells of the nematode C. elegans are filled with granular organelles named HEBE granules, which disintegrate rapidly by food deprivation. To clarify the molecular mechanisms underlying the organelle dynamics, I performed RNAi screening using an RNAi feeding library. As a result, all positive clones which suppressed the starvation response of HEBE granules by RNAi also showed the defect in oogenesis. Although HEBE granules do not participate in the transport of vitellogenin which is synthesized in the intestinal cells and utilized as a nutrient source of embryos, HEBE granules may store other excessive nutrients for the future embryos. Alternatively, signaling molecules from gonad may regulate the dynamics of HEBE granules.
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Report
(5 results)
Research Products
(22 results)
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[Presentation] Prominent accumulation of birefringent granules in the C. elegans intestinal cells upon RNAi of cdc-48.1 and cdc-48.2.2016
Author(s)
Hirohisa Shiraishi, Kenji Nishikori, Yuki Sato, Akane Takahashi, Ryo Kikuchi, Takahiro Tanji, Ayako Ohashi-Kobayashi
Organizer
Aging, Metabolism, Stress, Pathogenesis, and Small RNAs in C. elegans Topic Meeting 2016
Place of Presentation
マディソン（米国ウィスコンシン州）
Related Report
Int'l Joint Research
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[Presentation] Age- and nutrition-associated change in the morphology and population of intestinal granules in Caenorhabditis elegans.2014
Author(s)
Hirohisa Shiraishi, Maya Kamikawara, Seijun Suzuki, Eri Matsuura, Katsutoshi Ogasawara, Kinji Ishida, Koujiro Tohyama, Kenji Nishikori, Takahiro Tanji, Ayako Ohashi-Kobayashi
Organizer
C. elegans Development, Cell Biology and Gene Expression Meeting in association with the 6th Asia-Pacific C. elegans Meeting
Place of Presentation
奈良県新公会堂（奈良県奈良市）
Year and Date
2014-07-16
Related Report
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