The role of AhR on HFD-induced hepatic lipotoxicity
| Project/Area Number |
26860088
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental and hygienic pharmacy
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| Research Institution | Nihon University |
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Principal Investigator |
WADA Taira 日本大学, 薬学部, 助教 (20597398)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | AhR / SOCS3 / NASH / 脂肪肝炎 / 脂肪毒性 / 脂肪肝 |
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| Outline of Final Research Achievements |
Aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor regulating the expression of genes involved in xenobiotic response. Recent studies have suggested that AhR plays essential roles in not only xenobiotic detoxification but also energy metabolism. Thus, in this study, we studied the roles of AhR in lipid metabolism. Under high fat diet (HFD) challenge, liver-specific AhR-knockout (AhR LKO) mice exhibited severe steatosis, inflammation, and injury in the liver. Induction of suppressor of cytokine signal 3 (Socs3) expression by HFD was attenuated in the livers of AhR LKO mice. Rescue of the Socs3 gene in the liver of AhR LKO mice cancelled the HFD-induced hepatic lipotoxicities. These results indicated that AhR plays protective roles against HFD-induced hepatic steatosis and the subsequent lipotoxicity effects, such as inflammation, and that the mechanism of the protection involves the direct transcriptional regulation of Socs3 expression by AhR.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] nhibitory effects of compounds isolated from the dried branches and leaves of murta (Myrceugenia euosma) on lipid accumulation in 3T3-L1 cells.2016
Author(s)
Oikawa, N., Nobushi, Y., Wada, T., Sonoda, K., Okazaki, Y., Tsutsumi, S., Park, Y. K., Kurokawa, M., Shimba, S., Yasukawa, K.
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Journal Title
J. Nat. Med.
Volume: 印刷中
Issue: 3
Pages: 502-509
DOI
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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