| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Outline of Final Research Achievements |
We investigated the uptake mechanism of a substrate of NPC1L1 in the lipid emulsion particles and whether these particles containing cholesterol can improve the intestinal absorption of other poorly-absorbed lipoohilic (water-insoluble) components via NPC1L1. In this study, our results suggested that not only cholesterol but also some components in lipid particles are taken up into enterocytes via NPC1L1. We also examined an approach to improve intestinal absorption of a poorly absorbed water-insoluble component, coenzyme Q10 (CoQ10), by this mechanism. The uptake of CoQ10 in lipid emulsion particles containing cholesterol was significantly increased compared to that without cholesterol. Its increased uptake was significantly inhibited by ezetimibe. There is a potential for improvement of the absorption of poorly absorbed components by lipid emulsion particles containing cholesterol.
|
