Kidney transporter and gut microbiota as therapeutic targets for chronic kidney disease
Project/Area Number |
26860094
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Tohoku University |
Principal Investigator |
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 尿毒素 / 腸内細菌 / ミトコンドリア / tRNA / MA-5 / 慢性腎不全 / 血液透析 / 腸内細菌叢 |
Outline of Final Research Achievements |
(1) We comprehensively evaluated serum concentrations of 122 ionic compounds in hemodialysis (HD) patients. We identified 38 solutes and 23 solutes that were higher and lower, respectively, in HD patients than non-dialyzed chronic kidney disease (CKD) patients. (2) We revealed that a newly synthesized indole derivative (MA-5) increased cellular ATP level and survival of fibroblasts from patients with mitochondrial diseases. These data suggest that MA-5 has the potential to become a novel therapeutic drug for treatment of mitochondrial diseases. (3) We revealed that ClC-2 chloride channel activator lubiprostone improved the gut microbiota, resulting in amelioration of CKD progression. (4) Using next-generation sequencing, we examined whether ribonuclease angiogenin (ANG) cleaves CCA-termini of tRNAs in vivo. The proportion of tRNA-derived fragments with CCA did not increase in ANG-treated cells, suggesting that ANG does not cleave CCA-termini in vivo.
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Report
(4 results)
Research Products
(6 results)
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[Journal Article] Mitochonic Acid 5 (MA-5), a Derivative of the Plant Hormone Indole-3-Acetic Acid, Improves Survival of Fibroblasts from Patients with Mitochondrial Diseases.2015
Author(s)
T Suzuki, H Yamaguchi, M Kikusato, (他11名), Y Akiyama, Y Takeuchi, A Yuri, K Kikuchi, T Toyohara, C Suzuki, M Kohzuki, J Anzai, N Mano, S Kure, T Yanagisawa, Y Tomioka, M Toyomizu, S Ito, H Osaka, K Hayashi, and T Abe
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Journal Title
Tohoku J Exp Med
Volume: 236
Pages: 225-232
NAID
Related Report
Peer Reviewed
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[Journal Article] Alteration of the Intestinal Environment by Lubiprostone Is Associated with Amelioration of Adenine-Induced CKD2014
Author(s)
Eikan Mishima, Shinji Fukuda, Hisato Shima, Akiyoshi Hirayama, Yasutoshi Akiyama, Yoichi Takeuchi, Noriko N Fukuda, Takehiro Suzuki, Chitose Suzuki, Akinori Yuri, Koichi Kikuchi, Yoshihisa Tomioka, Sadayoshi Ito, Tomoyoshi Soga, and Takaaki Abe
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Journal Title
J Am Soc Nephrol
Volume: 26
Issue: 8
Pages: 1-8
DOI
Related Report
Peer Reviewed
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