| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Outline of Final Research Achievements |
The xenobiotic-sensing nuclear receptor PXR is well-known to play important roles in drug/xenobiotic clearance and hepatic energy metabolism. Recent studies have revealed that PXR also has a role in the regulation of immune/inflammatory responses. However, the precise details are still not fully understood. In this study, we have investigated the molecular mechanism underlying PXR-mediated regulation of immune/inflammatory responses using an in vivo mouse model of immune-mediated liver injury and in vitro cell-based experimental models. Our findings will provide us with useful information to investigate how PXR immune/inflammatory responses.
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