Identification of responsible factors of dosing time-dependent effects of cisplatin

• Project/Area Number: 26860097
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Okazaki Fumiyasu 富山大学, 大学院医学薬学研究部(薬学), 助教 (20610348)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 時間薬理 / 体内時計 / 分子時計 / 時間治療

Outline of Final Research Achievements

Previous reports suggested that chronomodulated chemotherapy using cisplatin improve anticancer effects, but the responsible factors remain unclear in pharmacokinetics and pharmacodynamics study. The purpose of this study is to identify the responsible factors of dosing time-dependent effects of cisplatin. SPT16, which dimerizes with SSRP1 involved in cisplatin resistance, influences dosing time-dependent effects of cisplatin in pharmacodynamics study. On the other hand, the pharmacokinetics study showed no significant difference. This study suggested that pharmacodynamics factors influence dosing time-dependent effects of cisplatin, and identified the responsible factor to determine the property dosing time of cisplatin.

Research Products

• [Journal Article] Circadian Clock in a Mouse Colon Tumor Regulates Intracellular Iron Levels to Promote Tumor Progression. (2016)
  • Author(s): Okazaki F, Matsunaga N, Okazaki H, Azuma H, Hamamura K, Tsuruta A, Tsurudome Y, Ogino T, Hara Y, Suzuki T, Hyodo K, Ishihara H, Kikuchi H, To H, Aramaki H, Koyanagi S, Ohdo S
  • Journal Title: The Journal of biological chemistry Volume: 291 Issue: 13 Pages: 7017-7028
  • DOI: 10.1074/jbc.m115.713412
  • Peer Reviewed / Open Access / Acknowledgement Compliant