Roles of anti-inflammatory system after drug-induced kidney injury

• Project/Area Number: 26860101
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: Nakagawa Shunsaku 京都大学, 医学(系)研究科(研究院), その他 (50721916)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 薬剤性腎障害 / 尿細管間質性腎炎 / シスプラチン / 抗炎症性サイトカイン / 腎線維化 / 間質性腎炎

Outline of Final Research Achievements

Drug-induced kidney injury (DKI) can cause progressive renal dysfunction and sever systemic outcomes. However, there are few approaches to repair or resolve the inflammation and fibrosis after DKI. In this study, we tried to identify the intrinsic anti-inflammatory system in the kidney.
After the administration with cisplatin, the expression levels of pro-inflammatory cytokines, IL-6 and CCL2 were significantly increased in the mouse kidneys at day2 after the treatment. On the other hands, the expression levels of anti-inflammatory cytokines, IL-10 and IL-27 were increased in the kidney at 7 days after the administration. Taken together, there results suggested the active roles of anti-inflammatory system in the kidney during cisplatin-induced kidney injury.

Research Products

• [Journal Article] Molecular Markers of Tubulointerstitial Fibrosis and Tubular Cell Damage in Patients with Chronic Kidney Disease (2015)
  • Author(s): Nakagawa S, Nishihara K, Miyata H, Shinke H, Tomita E, Kajiwara M, Matsubara T, Iehara N, Igarashi Y, Yamada H, Fukatsu A, Yanagita M, Matsubara K & Masuda S
  • Journal Title: PLoS One Volume: 10 Issue: 8 Pages: 1-14
  • DOI: 10.1371/journal.pone.0136994
  • NAID: 120005763422
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Novel 5-fluorouracil-resistant human esophageal squamous cell carcinoma cells with dihydropyrimidine dehydrogenase overexpression (2015)
  • Author(s): Kikuchi O, Ohashi S, Nakai Y, Nakagawa S, Matsuoka K, Kobunai T, Takechi T, Amanuma Y, Yoshioka M, Ida T, Yamamoto Y, Okuno Y, Miyamoto S, Nakagawa H, Matsubara K, Chiba T, Muto M
  • Journal Title: Am J Cancer Res Volume: 5 Pages: 2431-2440
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Extracellular nucleotides from dying cells act as molecular signals to promote wound repair in renal tubular injury (2014)
  • Author(s): Nakagawa S, Omura T, Yonezawa A, Yano I, Nakagawa T, Matsubara K.
  • Journal Title: Am J Physiol Renal Physiol Volume: 307 Issue: 12 Pages: F1404-F1411
  • DOI: 10.1152/ajprenal.00196.2014
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] ペメトレキセドとカルボプラチン併用による進行性の腎機能低下 (2016)
  • Author(s): 中村美紗子、中川俊作、奥田有紀、新家遥、米澤淳、中川貴之、松原和夫
  • Organizer: 日本臨床腫瘍薬学会学術大会2016
  • Place of Presentation: 鹿児島サンロイヤルホテル
  • Year and Date: 2016-03-12
• [Presentation] シスプラチン誘発性尿細管障害に伴うPdgfシグナル伝達経路を介した血管障害および炎症進展機序の解明 (2015)
  • Author(s): 竹澤亮、中川俊作、高尾翔太、米澤淳、中川貴之、松原和夫
  • Organizer: 第9回次世代を担う若手医療薬科学シンポジウム
  • Place of Presentation: 千葉大学
  • Year and Date: 2015-11-07
• [Presentation] 薬剤性腎障害発現機構 (2015)
  • Author(s): 中川俊作
  • Organizer: 日本臨床腫瘍薬学会学術大会2015
  • Place of Presentation: みやこめっせ（京都市勧業館）
  • Year and Date: 2015-03-14 – 2015-03-15
  • Invited
• [Presentation] 腎尿細管病変の増悪と修復におけるmTOR経路の役割に関する研究 (2014)
  • Author(s): 中川俊作
  • Organizer: 第24回 日本医療薬学会年会
  • Place of Presentation: 名古屋国際会議場
  • Year and Date: 2014-09-27 – 2014-09-28
  • Invited