Searching for treatment and prevention method of molecular targeted drugs-induced dermatological side effects based on the pathological mechanism
| Project/Area Number |
26860104
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kobe University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | STAT3 / HaCaT / 分子標的治療薬 / ソラフェニブ / 皮膚障害 / HFSR / 克服法 / 手足皮膚反応 / 治療法 / マルチキナーゼ阻害薬 / 分子標的治療医薬 |
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| Outline of Final Research Achievements |
We aimed to search for treatment and prevention method of molecular targeted drugs-induced dermatological side effects based on the pathological mechanism to focus the activity of STAT3. By screening assay searching chemicals resisted to decrease of phosphorylated STAT3 by sorafenib in HaCaT cells, P-VC-Mg and PGE1 were selected. Both chemicals showed resistance to sorafenib-induced apoptosis, and the efficacy of both chemicals to dermatological side effects was demonstrated by the experiment with 3D skin model. These chemicals may be able to apply as treatment and prevention method of molecular targeted drugs-induced dermatological side effects.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Association of Single Nucleotide Polymorphisms in STAT3 with Hand-Foot Skin Reactions in Patients with Metastatic Renal Cell Carcinoma Treated with Multiple Tyrosine Kinase Inhibitors: A Retrospective Analysis in Japanese Patients.2016
Author(s)
Yamamoto K., Shinomiya K., Ioroi T., Hirata S., Harada K., Suno M., Nishioka T., Kume M., Makimoto H., Nakagawa T., Hirano T., Bito T., Nishigori C., Miyake H., Fujisawa M., Hirai M.
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Journal Title
Targeted Oncology
Volume: 11
Issue: 1
Pages: 93-99
DOI
Related Report
Peer Reviewed
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[Journal Article] STAT3 polymorphism rs4796793 may be a predictive factor of tumor response to multiple tyrosine kinase inhibitors in metastatic renal cell carcinoma in Japanese population.2016
Author(s)
Yamamoto K., Ioroi T., Kanaya K., Shinomiya K., Komoto S., Hirata S., Harada K., Watanabe A., Suno M., Nishioka T., Kume M., Makimoto H., Nakagawa T., Hirano T., Miyake H., Fujisawa M., Hirtai M.
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Journal Title
Medical Oncology
Volume: 33
Issue: 3
Pages: 24-24
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Association of toxicity of sorafenib and sunitinib for human keratinocytes with inhibition of signal transduction and activator of transcription 3 (STAT3).2014
Author(s)
2.Yamamoto K., Mizumoto A., Nishimura K., Uda A., Mukai A., Yamashita K., Kume M., Makimoto H., Bito T., Nishigori C., Nakagawa T., Hirano T., Hirai M.
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Journal Title
PLoS One
Volume: 9
Issue: 7
Pages: e102110-e102110
DOI
NAID
Related Report
Peer Reviewed / Open Access
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