| Project/Area Number |
26860105
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Hiroshima University |
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Principal Investigator |
Yokooji Tomoharu 広島大学, 医歯薬保健学研究院(薬), 准教授 (70389120)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 食物アレルゲン / 消化管吸収 / 非ステロイド性抗炎症薬 / 運動負荷 / 感作 / エンドサイトーシス / 細胞感間輸送 / 細胞間隙輸送 / 食物アレルギー / アスピリン / マスト細胞 |
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| Outline of Final Research Achievements |
In this study, we evaluated the effects of exercise and NSAIDs, especially aspirin on oral sensitization to an egg-white allergen, ovalbumin (OVA) as well as OVA absorption, in rats. In OVA-sensitized rats, plasma concentrations of OVA and a paracellular marker, FD-40 were significantly higher than those in unsensitized rats after oral administration. Aspirin increased oral absorptions of OVA and FD-40 via the paracellular pathway, and exhibited a lower rectal temperature in OVA-sensitized rats. Sodium cromoglycate ameliorated these aspirin-facilitated absorptions and allergic reactions in a dose-dependent manner. Aspirin also exhibited higher plasma levels of OVA-specific IgE and IgG1 than those in control at 6 and 8 weeks after initiation of oral sensitization. In conclusion, facilitation of OVA absorption via paracellular pathway due to impairment of intestinal barrier function by aspirin is considered to be one of the reasons of enhanced oral sensitization with OVA by aspirin.
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