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Effect of valproic acid on radiation-induced oral mucositis

Research Project

Project/Area Number 26860106
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionEhime University

Principal Investigator

TANAKA AKIHIRO  愛媛大学, 医学部附属病院, 准教授 (50527562)

Research Collaborator Watanabe shinichi  愛媛大学, 医学部附属病院, 薬剤師
Sumikawa Satomi  愛媛大学, 医学部附属病院, 薬剤師
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords放射線誘発口腔粘膜障害 / バルプロ酸ナトリウム / 口腔粘膜炎 / 放射線 / バルプロ酸
Outline of Final Research Achievements

Oral mucositis, a side effect of cancer radiotherapy, occurs primarily during head and neck radiotherapy, causing severe mucosal damage from the oral cavity to the pharynx. However, there is currently no effective therapeutic agent. In our study, it was suggested that sodium valproate as an antiepileptic drug and having HDAC inhibition may be useful for radiation induced oral mucosal disorders.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (1 results) Presentation (4 results)

  • [Journal Article] 薬剤部での取り組み:放射線性口腔粘膜炎治療におけるHDAC阻害薬の可能性~ドラッグ・リポジショニングの視点から~2016

    • Author(s)
      渡邉真一,田中亮裕,荒木博陽
    • Journal Title

      愛媛医学

      Volume: 35 Pages: 153-158

    • Related Report
      2016 Annual Research Report
  • [Presentation] がん治療に伴う口内炎対策の現状と課題2016

    • Author(s)
      渡邉真一,濟川聡美,山下 登,田中亮裕,荒木博陽
    • Organizer
      第26回日本医療薬学会年会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2016-09-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] 放射線誘発口腔粘膜炎モデルの組織スコアリング法と評価2016

    • Author(s)
      渡邉真一,濟川聡美,山下 登,田中亮裕,荒木博陽
    • Organizer
      第1回日本がんサポーティブケア学会学術集会
    • Place of Presentation
      東京慈恵会医科大学
    • Year and Date
      2016-09-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] がん放射線療法によって誘発される口腔粘膜炎の病態と治療に関するアプローチ2015

    • Author(s)
      渡邉真一,濟川聡美,田中亮裕,荒木博陽
    • Organizer
      第24回創薬・薬理フォーラム
    • Place of Presentation
      岡山大学鹿田キャンパス(岡山県岡山市)
    • Year and Date
      2015-12-20
    • Related Report
      2015 Research-status Report
  • [Presentation] がん化学療法・放射線治療によって誘発される口内炎に対する治療薬の探索2015

    • Author(s)
      渡邉真一
    • Organizer
      第25回日本医療薬学会年会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2015-11-21
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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