Effect of valproic acid on radiation-induced oral mucositis
| Project/Area Number |
26860106
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Ehime University |
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Principal Investigator |
TANAKA AKIHIRO 愛媛大学, 医学部附属病院, 准教授 (50527562)
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| Research Collaborator |
Watanabe shinichi 愛媛大学, 医学部附属病院, 薬剤師
Sumikawa Satomi 愛媛大学, 医学部附属病院, 薬剤師
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 放射線誘発口腔粘膜障害 / バルプロ酸ナトリウム / 口腔粘膜炎 / 放射線 / バルプロ酸 |
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| Outline of Final Research Achievements |
Oral mucositis, a side effect of cancer radiotherapy, occurs primarily during head and neck radiotherapy, causing severe mucosal damage from the oral cavity to the pharynx. However, there is currently no effective therapeutic agent. In our study, it was suggested that sodium valproate as an antiepileptic drug and having HDAC inhibition may be useful for radiation induced oral mucosal disorders.
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Report
(4 results)
Research Products
(5 results)
