| Project/Area Number |
26860111
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Ohu University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | DDS / 交互累積膜 / 機能性高分子 / ミクロカプセル / 電気化学 / 電気刺激応答性 |
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| Outline of Final Research Achievements |
We aimed at the development of the electrochemical medical device capable of controlling the release of drug. For that purpose, we tried to the adsorption of the microcapsules by Layer-by-Layer (LbL) deposition and the dissociation by electrical-trigger.
Insulin-containing microcapsules were prepared by a LbL deposition on insulin-containing calcium carbonate (CaCO3) microparticles. The CaCO3 core was dissolved in diluted HCl solution to obtain insulin-containing hollow microcapsules. Insulin was released from the microcapsules at neutral pH while the release was suppressed at acidic pH. It was modified the TEMPO having electrochemical responsiveness to polymer. It was adsorbed the microcapsules using TEMPO modified polymer on the substrate, then applying electrical potential to adsorbed microcapsules. Though, it was not sufficient dissociation of the adsorbed microcapsule.
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