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Approach to new therapeutic strategy against pancreatic cancer by targeting lipid metabolism

Research Project

Project/Area Number 26860115
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Medical pharmacy
Research InstitutionYokohama College of Pharmacy

Principal Investigator

Nishi Koji  横浜薬科大学, 薬学部, 講師 (00398249)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords膵癌 / 脂質代謝 / アポトーシス / 脂肪酸合成 / 膵癌細胞
Outline of Final Research Achievements

In this study, we investigated the effects of various lipid metabolism inhibitors on proliferation and viability of human pancreatic cancer cells for developing new therapeutic strategy. In used inhibitors, inhibitors to fatty acid synthesis (TOFA, Celurenin, Irgasan) especially showed the remarkable induction of apoptosis and suppression of proliferation. This result indicates that the pathway of fatty acid synthesis is very important for pancreatic cancer cells. On the other hand, these inhibitors did not showed such effects only to PANC1 cell. These result suggest that inhibition of fatty acid synthesis is partially critical to pancreatic cancer cells and can be effective target for chemical therapy.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2016

All Presentation (1 results)

  • [Presentation] ヒト膵癌細胞株における脂質合成阻害剤の細胞増殖抑制およびアポトーシス誘導効果2016

    • Author(s)
      西 弘二、鈴木健太、時澤佑茉、澤本潤平、岩瀬由未子、弓田長彦、池田敏彦
    • Organizer
      日本薬学会第136年会
    • Place of Presentation
      横浜
    • Year and Date
      2016-03-27
    • Related Report
      2015 Annual Research Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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