Approach to new therapeutic strategy against pancreatic cancer by targeting lipid metabolism
| Project/Area Number |
26860115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
Nishi Koji 横浜薬科大学, 薬学部, 講師 (00398249)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 膵癌 / 脂質代謝 / アポトーシス / 脂肪酸合成 / 膵癌細胞 |
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| Outline of Final Research Achievements |
In this study, we investigated the effects of various lipid metabolism inhibitors on proliferation and viability of human pancreatic cancer cells for developing new therapeutic strategy. In used inhibitors, inhibitors to fatty acid synthesis (TOFA, Celurenin, Irgasan) especially showed the remarkable induction of apoptosis and suppression of proliferation. This result indicates that the pathway of fatty acid synthesis is very important for pancreatic cancer cells. On the other hand, these inhibitors did not showed such effects only to PANC1 cell. These result suggest that inhibition of fatty acid synthesis is partially critical to pancreatic cancer cells and can be effective target for chemical therapy.
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Report
(3 results)
Research Products
(1 results)
