| Project/Area Number |
26860116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Yokohama College of Pharmacy |
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Principal Investigator |
ISOBE Takashi 横浜薬科大学, 薬学部, 講師 (30440530)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アルギン酸 / ヒストン / 敗血症 / 多臓器不全 |
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| Outline of Final Research Achievements |
The extracellular release of histones in response to bacterial challenges has been reported to function as a mediator for endothelial dysfunction, organ failure, and death during sepsis. In the present study, the adsorption of histones as well as plasma proteins on alginic acid, pectin, dextran, and chitosan was examined in order to evaluate the potential of natural polysaccharides as therapeutic agents for multiple organ failure in sepsis. The results of this study demonstrate that alginic acid strongly adsorbs histones, but not plasma proteins, and suggest that it is a promising candidate drug for the treatment of multiple organ failure in sepsis.
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