Development of anti-diabetic nephropathy drug targeting for transglutaminase

• Project/Area Number: 26860118
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Meijo University
• Principal Investigator: MIZUNO Tomohiro 名城大学, 薬学部, 助教 (40711669)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 終末糖化産物 / トランスグルタミナーゼ2

Outline of Final Research Achievements

In the present study, we investigated the mechanism of increasing the expression of transglutaminase 2 (TG2) induced by advanced glycation endproducts (AGEs). In human renal tubular cells, we elucidated that AGEs increased the expression of TG2 via activation of NF-κb. This increasing was inhibited by inhibitor of receptor for AGEs (RAGE). These results suggested that AGEs binds to RAGE and increases the expression of TG2 via activation of NF-κb.

Research Products

• [Presentation] 終末糖化産物は、ヒト尿細管細胞にてトランスグルタミナーゼ2の発現を増加させる。 (2015)
  • Author(s): 寺尾勇紀、水野智博、高橋和男、秋山真一、丸山彰一、辰川英樹、人見清隆、湯澤由紀夫、永松 正
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 終末糖化産物は、ヒト尿細管細胞にてトランスグルタミナーゼ2の発現を増加させる。 (2014)
  • Author(s): 水野智博、高橋和男 、寺尾勇紀、秋山真一、丸山彰一、辰川英樹、人見清隆、永松 正、湯澤由紀夫
  • Organizer: 第57回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2014-07-04 – 2014-07-06