| Project/Area Number |
26860119
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
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| Keywords | トランスポーター / 炎症 / 裏打ちタンパク質 / サイトカイン / 一酸化窒素 / 肝臓 / 胆汁排泄 / radixin / P-糖タンパク質 |
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| Outline of Final Research Achievements |
The functions of transporters which are involved in drug disposition depend on surrounding environment such as ERM proteins (ezrin/radixin/moesin). Some transporters are anchored to plasma membranes by activated ERM proteins. However, the alterations in ERM proteins expression and the effects on transporter functions in inflammation remains unclear. We showed that the function of radixin and transporters were decreased in inflammation and that interleukin was involved in change of radixin.
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