| Project/Area Number |
26860120
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Mukogawa Women's University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 苦味 / 味覚センサ / 味マップ / 味相互作用 |
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| Outline of Final Research Achievements |
We classified the bitterness or astringency of drugs using taste sensor SA402B. Principal component analysis for taste sensor output of drugs (0.1, 0.3, 1.0 mM) was carried out and the result was represented in map. X-axis and Y-axis were thought to indicate bitterness and astringency respectively. It was estimated that amitriptyline hydrochloride and imipramine hydrochloride represent strong bitterness, while amlodipine besilate, diphenhydramine hydrochloride and donepezil hydrochloride also represent strong astringency. The bitterness of drugs was suppressed by chlorogenic acid. Correlation between bitterness inhibition rate and drug-chlorogenic acid interaction parameter suggested that the interaction between drug and chlorogenic acid contributes to suppressing the bitterness of drug.
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