| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
PXR, a member of the nuclear receptor superfamily, is expressed in immune cells, but the role of PXR in T lymphocyte remains unknown. Thus, we determined the roles of PXR in T lymphocyte. The combination of PMA and ionomycin induced PXR expression in human T cell acute leukemia Jurkat cells. Rifampicin, one of selective activators of PXR, increased PMA/ionomycin-mediated IL-2 expression, while expression of IL-4 and IL17A were nearly unchanged.
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