The roles of PXR in immune responses
Project/Area Number |
26860122
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Medical pharmacy
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Research Institution | Tokyo Metropolitan Institute of Medical Science |
Principal Investigator |
SAEKI Mayumi 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (00462771)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | PXR / T細胞 / 核内受容体 / 免疫 |
Outline of Final Research Achievements |
PXR, a member of the nuclear receptor superfamily, is expressed in immune cells, but the role of PXR in T lymphocyte remains unknown. Thus, we determined the roles of PXR in T lymphocyte. The combination of PMA and ionomycin induced PXR expression in human T cell acute leukemia Jurkat cells. Rifampicin, one of selective activators of PXR, increased PMA/ionomycin-mediated IL-2 expression, while expression of IL-4 and IL17A were nearly unchanged.
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Report
(5 results)
Research Products
(11 results)
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[Journal Article] Essential contribution of CD4+ T cells to antigen-induced nasal hyperresponsiveness in experimental allergic rhinitis.2016
Author(s)
Nishimura, T., Kaminuma, O., Saeki, M., Kitamura, N., Matsuoka, K., Yoneyama, H., Mori, A., and Hiroi, T.
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Journal Title
Plos One.
Volume: 11
Issue: 1
Pages: e0146686-e0146686
DOI
Related Report
Peer Reviewed / Open Access
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