Involvement of mitochondrial dynamics in brain development and pathogenesis of psychiatric disorders

• Project/Area Number: 26860133
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including histology/embryology)
• Research Institution: Osaka University
• Principal Investigator: Takamura Hironori 大阪大学, 連合小児発達学研究科, 助教 (80514398)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ミトコンドリア / 脳発達 / 精神疾患 / SUMO化

Outline of Final Research Achievements

In this study, we focused on mitochondrial dynamics and observed the effects of the dynamics on brain development and psychiatric disorders. As results, we found interaction between the mitochondrial molecule and the molecule in endoplasmic reticulum, and also revealed that the interaction is important to regulate mitochondrial morphology and function. On the other hand, we observed SUMOylation, which has been reported to have important roles in brain function and mitochondrial function. We identified some potential SUMOylated proteins and studied the effect of SUMOylation on the proteins.

Research Products

• [Presentation] SUMOylation Pathways in Synaptic Development and Neurodegeneration. (2016)
  • Author(s): Matsuzaki S, Takamura H, Katayama T, Fraser P.
  • Organizer: 第89回日本薬理学会年会
  • Place of Presentation: 神奈川県横浜市
  • Year and Date: 2016-03-09
• [Presentation] 神経系おける Sumal Ubiquitin like Modifer 1（SUMO1）の働き (2015)
  • Author(s): 松崎 伸介、天野 元揮、向井 春香、佐藤 大樹、韓 薩日那、高村 明孝、三好 耕、片山 泰一
  • Organizer: 第42回 日本脳科学会
  • Place of Presentation: 宮崎県宮崎市
  • Year and Date: 2015-11-12
• [Presentation] SUMO1 Overexpression Affects Synaptic Function, Spine Density and Memory. (2015)
  • Author(s): Matsuzaki S, Takamura H, Miyoshi K, Hashimoto H, Raught B, Arancio O, Katayama T, Fraser P.
  • Organizer: Neuroscience 2015, Society for Neuroscience
  • Place of Presentation: Chicago, USA
  • Year and Date: 2015-10-17
• [Presentation] SUMO1 Affects Synaptic Function, Spine Density and Memory. (2015)
  • Author(s): Matsuzaki S, Takamura H, Amano G, Sato H, Han S, Miyoshi K, Fraser P, Katayama T.
  • Organizer: The 58th Annual Meeting of the Japanese Society for Neurochemistry
  • Place of Presentation: Saitama, Japan
  • Year and Date: 2015-09-11
• [Presentation] SUMOylation affects Tau accumulation in neurodegenerative diseases. (2015)
  • Author(s): Takamura H, Yamada K, Matsuzaki S, Hazrati Lili-N, Katayama T, Fraser P.
  • Organizer: The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-07-28
• [Presentation] SUMO1 Overexpression Affects Synaptic Function, Spine Density and Memory. (2015)
  • Author(s): Matsuzaki S, Takamura H, Miyoshi K, Raught B, Arancio O, Fraser P, Katayama T.
  • Organizer: The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: Kobe, Japan
  • Year and Date: 2015-07-28