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Involvement of mitochondrial dynamics in brain development and pathogenesis of psychiatric disorders

Research Project

Project/Area Number 26860133
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionOsaka University

Principal Investigator

Takamura Hironori  大阪大学, 連合小児発達学研究科, 助教 (80514398)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsミトコンドリア / 脳発達 / 精神疾患 / SUMO化
Outline of Final Research Achievements

In this study, we focused on mitochondrial dynamics and observed the effects of the dynamics on brain development and psychiatric disorders. As results, we found interaction between the mitochondrial molecule and the molecule in endoplasmic reticulum, and also revealed that the interaction is important to regulate mitochondrial morphology and function. On the other hand, we observed SUMOylation, which has been reported to have important roles in brain function and mitochondrial function. We identified some potential SUMOylated proteins and studied the effect of SUMOylation on the proteins.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015

All Presentation (6 results)

  • [Presentation] SUMOylation Pathways in Synaptic Development and Neurodegeneration.2016

    • Author(s)
      Matsuzaki S, Takamura H, Katayama T, Fraser P.
    • Organizer
      第89回日本薬理学会年会
    • Place of Presentation
      神奈川県横浜市
    • Year and Date
      2016-03-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 神経系おける Sumal Ubiquitin like Modifer 1(SUMO1)の働き2015

    • Author(s)
      松崎 伸介、天野 元揮、向井 春香、佐藤 大樹、韓 薩日那、高村 明孝、三好 耕、片山 泰一
    • Organizer
      第42回 日本脳科学会
    • Place of Presentation
      宮崎県宮崎市
    • Year and Date
      2015-11-12
    • Related Report
      2015 Annual Research Report
  • [Presentation] SUMO1 Overexpression Affects Synaptic Function, Spine Density and Memory.2015

    • Author(s)
      Matsuzaki S, Takamura H, Miyoshi K, Hashimoto H, Raught B, Arancio O, Katayama T, Fraser P.
    • Organizer
      Neuroscience 2015, Society for Neuroscience
    • Place of Presentation
      Chicago, USA
    • Year and Date
      2015-10-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] SUMO1 Affects Synaptic Function, Spine Density and Memory.2015

    • Author(s)
      Matsuzaki S, Takamura H, Amano G, Sato H, Han S, Miyoshi K, Fraser P, Katayama T.
    • Organizer
      The 58th Annual Meeting of the Japanese Society for Neurochemistry
    • Place of Presentation
      Saitama, Japan
    • Year and Date
      2015-09-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] SUMOylation affects Tau accumulation in neurodegenerative diseases.2015

    • Author(s)
      Takamura H, Yamada K, Matsuzaki S, Hazrati Lili-N, Katayama T, Fraser P.
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] SUMO1 Overexpression Affects Synaptic Function, Spine Density and Memory.2015

    • Author(s)
      Matsuzaki S, Takamura H, Miyoshi K, Raught B, Arancio O, Fraser P, Katayama T.
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2015-07-28
    • Related Report
      2015 Annual Research Report

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Published: 2014-04-04   Modified: 2017-05-10  

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