| Project/Area Number |
26860133
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ミトコンドリア / 脳発達 / 精神疾患 / SUMO化 |
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| Outline of Final Research Achievements |
In this study, we focused on mitochondrial dynamics and observed the effects of the dynamics on brain development and psychiatric disorders. As results, we found interaction between the mitochondrial molecule and the molecule in endoplasmic reticulum, and also revealed that the interaction is important to regulate mitochondrial morphology and function. On the other hand, we observed SUMOylation, which has been reported to have important roles in brain function and mitochondrial function. We identified some potential SUMOylated proteins and studied the effect of SUMOylation on the proteins.
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