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Immunohistological analysis of autoimmune disease caused by dysfunction of thymic epithelial cells

Research Project

Project/Area Number 26860138
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionDokkyo Medical University

Principal Investigator

Sawanobori Yasushi  獨協医科大学, 医学部, 助教 (40525052)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords胸腺上皮細胞 / 免疫寛容 / T細胞分化 / 胸腺 / 自己免疫 / 免疫染色
Outline of Final Research Achievements

Thymic epithelial cells had been mainly investigated in mice, and identified with keratin expression pattern and biding to lectin. Studying whether this patterns are common between species of not, we immunohistochemistrically stained thymi of mice and rats with already-known methods and newly produced antibody ED18, ED19, and ED21. As a result, medullary thymic epithelial cells were revealed to consist of two subsets, as we named mTEC1 and mTEC2. Binding to lectin and functional molecules were dominant in mTEC1. We also revealed that mTEC1 diminish mainly in cyclosporine A administered rats.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Three distinct subsets of thymic epithelial cells in rats and mice defined by novel antibodies.2014

    • Author(s)
      Sawanobori Y, Ueta H, Dijkstra CD, Park CG, Satou M, Kitazawa Y, Matsuno K.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 10 Pages: e109995-e109995

    • DOI

      10.1371/journal.pone.0109995

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Novel antibodies revealed three distinct thymic epithelial cell subsets in rats and mice.2014

    • Author(s)
      SAWANOBORI Yasushi, UETA Hisashi, KITAZAWA Yusuke, MATSUNO Kenjiroh
    • Organizer
      第43回日本免疫学会総会・学術集会
    • Place of Presentation
      京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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