Immunohistological analysis of autoimmune disease caused by dysfunction of thymic epithelial cells
| Project/Area Number |
26860138
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including histology/embryology)
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 胸腺上皮細胞 / 免疫寛容 / T細胞分化 / 胸腺 / 自己免疫 / 免疫染色 |
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| Outline of Final Research Achievements |
Thymic epithelial cells had been mainly investigated in mice, and identified with keratin expression pattern and biding to lectin. Studying whether this patterns are common between species of not, we immunohistochemistrically stained thymi of mice and rats with already-known methods and newly produced antibody ED18, ED19, and ED21. As a result, medullary thymic epithelial cells were revealed to consist of two subsets, as we named mTEC1 and mTEC2. Binding to lectin and functional molecules were dominant in mTEC1. We also revealed that mTEC1 diminish mainly in cyclosporine A administered rats.
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Report
(3 results)
Research Products
(2 results)
