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Analysis of ischemia-induced neuronal cell death

Research Project

Project/Area Number 26860139
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionJuntendo University

Principal Investigator

SUNABORI Takehiko  順天堂大学, 医学部, 助教 (00407115)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords低酸素 / 脳虚血 / 脳梗塞 / 神経細胞死 / Toll様受容体 / オートファジー / 炎症性サイトカイン / 海馬
Outline of Final Research Achievements

Toll like receptors are one of the main contributors that induce inflammation under tissue injury and infection. We have previously reported that not only the excessive inflammation induced by TLR2, but also autophagy induction could aggravate disease states after neonatal hypoxic/ischemic (H/I) brain injury. Herein, we showed that the activation of TLR2 could directly induce autophagy after H/I injury. In contrast, the autophagy-impairment also revealed suppression of proinflammatory cytokine. Taken together, these data suggest that the activation of the TLR2-signaling pathway and autophagy induction leads to neuronal cell death in a synergistic action after neonatal-H/I brain injury.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results) (of which Invited: 1 results)

  • [Journal Article] Suppression of ischemia-induced hippocampal pyramidal neuron death by hyaluronan tetrasaccharide through inhibition of toll-like receptor 2 signaling pathway2016

    • Author(s)
      Takehiko Sunabori, Masato Koike, Akira Asari, Yoji Oonuki, Yasuo Uchiyama
    • Journal Title

      American Journal of Pathology

      Volume: 印刷中

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity.2016

    • Author(s)
      Mehanna, S, Suzuki, C., Shibata, M., Sunabori, T., Imanaka, T., Araki, K., Yamamura, K., Uchiyama, Y. and Ohmuraya, M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 469 Issue: 3 Pages: 405-411

    • DOI

      10.1016/j.bbrc.2015.12.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Presentation] オリゴデンドロサイト分化におけるmTORC1活性化の意義2016

    • Author(s)
      砂堀 毅彦、名田 茂之、岡田 雅人、内山 安男、小池 正人
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      ビッグパレットふくしま
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Toll like receptors control neuronal cell death via regulating the activation and production of nitric oxide in microglia cells of cathepsin D-deficient mice2015

    • Author(s)
      砂堀毅彦
    • Organizer
      第120回日本解剖学会
    • Place of Presentation
      神戸
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] オリゴデンドロサイト分化におけるmTORC1活性化の意義2015

    • Author(s)
      砂堀毅彦
    • Organizer
      第20回グリアクラブ
    • Place of Presentation
      函館
    • Year and Date
      2015-01-26 – 2015-01-28
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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