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Study on the molecular mechanisms of fibrogenesis by myofibroblasts which accumulate around fibers

Research Project

Project/Area Number 26860140
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General anatomy (including histology/embryology)
Research InstitutionKinki University

Principal Investigator

OGAWA Tomohiro  近畿大学, 工学部, 講師 (70448752)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords星細胞 / インテグリン / コラーゲン / 肝臓 / オステオポンチン / 線維化
Outline of Final Research Achievements

We focused on the presence of myofibroblasts, which found in the liver pathology. Liver myofibroblasts are thought to be important cells in liver fibrogenesis. In this study, we reveal the presence of osteopontin (OPN)-positive liver myofibroblasts, and were studying the isolation and functional analysis of OPN-positive liver myofibroblasts. First, we tried to separate OPN-positive cells from normal liver, but the cells were no presence. Next, we searched for liver failure model, which had high expression of OPN genes. As a result, we confirmed the high expression of OPN genes in fibrosis model and NASH model in mice. It was clear that OPN-positive cells were mainly present in peripheral portal region. OPN was suggested to be useful a marker of myofibroblasts in the early stages of fibrosis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (1 results)

All 2015

All Presentation (1 results) (of which Int'l Joint Research: 1 results)

  • [Presentation] Propolis components suppresses activated hepatic stellate cell invasion by inhibition of MMP-2 and MMP-9 expression and its activation2015

    • Author(s)
      小川智弘
    • Organizer
      第18回国際類洞壁細胞シンポジウム
    • Place of Presentation
      アメリカ(パシフィックグローブ)
    • Year and Date
      2015-11-11
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research

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Published: 2014-04-04   Modified: 2017-05-10  

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