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Imaging analyses for activated platelets' surface to initiate blood coagulation both in in-vivo and in-vitro systems.

Research Project

Project/Area Number 26860146
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

Brzoska Tomasz  浜松医科大学, 医学部, 特任研究員 (80707000)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsFibrinolysis / Coagulation / Plasminogen / Platelet / Platelets / fibrinolysis / coagulation / plasminogen / platelets
Outline of Final Research Achievements

Contribution of activated platelets on the initiation and amplification of coagulation cascade, fibrin formation as well as its lysis was analyzed. PS exposing platelets appeared the initiation sites of both the activation of coagulation cascade and fibrin formation. We also found that plasminogen binds to PS exposing platelets which then initiated fibrinolysis as starting points. These seem important to quickly dissolve generated excess amounts of thrombi in order to keep vascular patency.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Endogenously Generated Plasmin at the Vascular Wall Injury Site Amplifies Lysine Binding Site-Dependent Plasminogen Accumulation in Microthrombi.2015

    • Author(s)
      Brzoska T, Tanaka-Murakami A, Suzuki Y, Sano H, Kanayama N, Urano T.
    • Journal Title

      PLoSONE

      Volume: 10 Issue: 3 Pages: 1371-1371

    • DOI

      10.1371/journal.pone.0122196

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Endogenously generated plasmin at the vascular wall injury site amplifies lysine binding site-dependent plasminogen accumulation in microthrombi.2014

    • Author(s)
      Brzoska Tomasz
    • Organizer
      The 61st Annual Meeting of Japanese Physiology Society of Chubu Area
    • Place of Presentation
      Nagoya
    • Year and Date
      2014-11-07 – 2014-11-08
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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