Imaging analyses for activated platelets' surface to initiate blood coagulation both in in-vivo and in-vitro systems.

Research Project

Project/Area Number	26860146
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	General physiology
Research Institution	Hamamatsu University School of Medicine
Principal Investigator	Brzoska Tomasz 浜松医科大学, 医学部, 特任研究員 (80707000)
Project Period (FY)	2014-04-01 – 2016-03-31
Project Status	Completed (Fiscal Year 2015)
Budget Amount *help	¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	Fibrinolysis / Coagulation / Plasminogen / Platelet / Platelets / fibrinolysis / coagulation / plasminogen / platelets
Outline of Final Research Achievements	Contribution of activated platelets on the initiation and amplification of coagulation cascade, fibrin formation as well as its lysis was analyzed. PS exposing platelets appeared the initiation sites of both the activation of coagulation cascade and fibrin formation. We also found that plasminogen binds to PS exposing platelets which then initiated fibrinolysis as starting points. These seem important to quickly dissolve generated excess amounts of thrombi in order to keep vascular patency.

Report

(3 results)