| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
The initiation of inflammatory response and dyskeratosis by UVA irradiation has large impact on photoaging. In this study, I examined the involvement of ATP in the production of cytokines and abnormal differentiation of UVA-irradiated keratinocytes. The concentration of extracellular ATP was transiently increased after UVA irradiation. UVA induced the production of cytokines (IL-1α, IL-6 and IL-8), and changed the expression of differentiation markers, but these UVA-induced cellular responses were suppressed by pretreatment of apyrase and P2 antagonist. These results showed that ATP might be a key player in the onset of UVA-irradiation-induced photoaging.
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