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Study of Rules and Functions with Aquaporin 0

Research Project

Project/Area Number 26860149
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKeio University

Principal Investigator

Nakazawa Yosuke  慶應義塾大学, 薬学部, 助教 (60411708)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords水晶体 / 水チャネル / 白内障 / チャネル / 老化 / アクアポリン0 / 細胞接着
Outline of Final Research Achievements

(1) The permeation assay of AQP0 was used the stable L-cell line expressing AQP0. As the result, AQP0 can permeate ascorbic acid ex vivo, and also indicate that there is a difference between the import and export of ascorbic acid via AQP0 channel.
(2) The cell adhesion assay of AQP0 was revealed that AQP0 could bind directly to the opposing membrane.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (8 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 1 results,  Open Access: 2 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results)

  • [Journal Article] アクアポリン0(AQP0)の細胞間接着に関与するアミノ酸の特定2016

    • Author(s)
      中澤洋介, 岡美佳子, 田村悦臣, 竹鼻眞
    • Journal Title

      日本眼科学会誌

      Volume: 120 Pages: 50-50

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Hesperetin prevents selenite-induced cataract in rats2015

    • Author(s)
      Yosuke Nakazawa, Mikako Oka, Masayasu Bando, Makoto Takehana
    • Journal Title

      Molecular Vision

      Volume: 21 Pages: 804-810

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of Rules and Functions with Aquaporin 02015

    • Author(s)
      中澤 洋介
    • Journal Title

      The Journal of The Japanese Society for Cataract Research

      Volume: 27 Issue: 1 Pages: 9-13

    • DOI

      10.14938/cataract.07-001

    • NAID

      130005087851

    • ISSN
      0915-4302, 2188-613X
    • Related Report
      2015 Annual Research Report
    • Open Access
  • [Presentation] Effect of interaction between aquaporin 0 and filensin on the functions of aquaporin 02015

    • Author(s)
      Yosuke Nakazawa, Mikako Oka, Hiroomi Tamura, Makoto Takehana.
    • Organizer
      The 3rd International Conference on the Lens 2015
    • Place of Presentation
      コナ市(アメリカ)
    • Year and Date
      2015-12-06
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アクアポリン0(AQP0)の細胞間接着に関与するアミノ酸の確定2015

    • Author(s)
      中澤洋介, 岡美佳子, 田村悦臣, 竹鼻眞
    • Organizer
      第54回日本白内障学会総会
    • Place of Presentation
      ミッドランドスクエア(愛知県・名古屋市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] レーザー虹彩切開術による角膜内皮細胞DNAの傷害2015

    • Author(s)
      庄子英一、奥みずほ、中澤洋介、岡美佳子、竹鼻眞
    • Organizer
      第119回日本眼科学会総会
    • Place of Presentation
      ロイトン札幌
    • Year and Date
      2015-04-16 – 2015-04-19
    • Related Report
      2014 Research-status Report
  • [Presentation] アクアポリン0 (AQP0) の細胞間接着分子としての働き2014

    • Author(s)
      中澤洋介、岡美佳子、竹鼻眞
    • Organizer
      第53回日本白内障学会総会
    • Place of Presentation
      TKPガーデンシティ品川
    • Year and Date
      2014-09-27 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] 水晶体のアクアポリン0の役割および機能に関する新しい知見2014

    • Author(s)
      中澤洋介
    • Organizer
      第53回日本白内障学会総会
    • Place of Presentation
      TKPガーデンシティ品川
    • Year and Date
      2014-09-27 – 2014-09-28
    • Related Report
      2014 Research-status Report
    • Invited

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Published: 2014-04-04   Modified: 2017-05-10  

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