Role of fibrinolytic system in bone regeneration impaired by diabetes
| Project/Area Number |
26860152
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 糖尿病 / 骨再生 / 線溶系 / 骨修復再生障害 / PAI-1 / 骨・軟骨再生 |
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| Outline of Final Research Achievements |
The present study examined the role of plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, in the impairment of bone repair induced by diabetes using streptozotocin-induced type 1 diabetic mice. Streptozotocin treatment impaired the bone repair and osteogenesis in femur of diabetic female mice, whereas PAI-1 deficiency improved them in diabetic female mice. Our findings suggest that PAI-1 is involved in bone repair and regeneration impaired by diabetes in mice.
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Report
(3 results)
Research Products
(11 results)
