Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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Outline of Final Research Achievements |
The present study examined the role of plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, in the impairment of bone repair induced by diabetes using streptozotocin-induced type 1 diabetic mice. Streptozotocin treatment impaired the bone repair and osteogenesis in femur of diabetic female mice, whereas PAI-1 deficiency improved them in diabetic female mice. Our findings suggest that PAI-1 is involved in bone repair and regeneration impaired by diabetes in mice.
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