Role of fibrinolytic system in bone regeneration impaired by diabetes

• Project/Area Number: 26860152
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General physiology
• Research Institution: Kinki University
• Principal Investigator: TAMURA Yukinori 近畿大学, 医学部, 助教 (40580262)
• Project Period (FY): 2014-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 糖尿病 / 骨再生 / 線溶系 / 骨修復再生障害 / PAI-1 / 骨・軟骨再生

Outline of Final Research Achievements

The present study examined the role of plasminogen activator inhibitor-1 (PAI-1), a principal inhibitor of fibrinolysis, in the impairment of bone repair induced by diabetes using streptozotocin-induced type 1 diabetic mice. Streptozotocin treatment impaired the bone repair and osteogenesis in femur of diabetic female mice, whereas PAI-1 deficiency improved them in diabetic female mice. Our findings suggest that PAI-1 is involved in bone repair and regeneration impaired by diabetes in mice.

Research Products

• [Journal Article] Stromal cell-derived factor-1 mediates changes of bone marrow stem cells during the bone repair process. (2016)
  • Author(s): Okada K, Kawao N, Yano M, Tamura Y, Kurashimo S, Okumoto K, Kojima K, Kaji H.
  • Journal Title: Am J Physiol Endocrinol Metab Volume: 1 Issue: 1 Pages: E15-E23
  • DOI: 10.1152/ajpendo.00253.2015
  • Peer Reviewed
• [Journal Article] Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice. (2015)
  • Author(s): Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H.
  • Journal Title: Diabetes Volume: 642194-206 Issue: 6 Pages: 2194-2206
  • DOI: 10.2337/db14-1192
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The Tissue Fibrinolytic System Contributes to the Induction of Macrophage Function and CCL3 during Bone Repair in Mice. (2015)
  • Author(s): Kawao N, Tamura Y, Horiuchi Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H.
  • Journal Title: PLoS One Volume: 10 Issue: 4 Pages: e0123982-e0123982
  • DOI: 10.1371/journal.pone.0123982
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] α2-Antiplasmin is involved in bone loss induced by ovariectomy in mice. (2015)
  • Author(s): Shiomi A, Kawao N, Yano M, Okada K, Tamura Y, Okumoto K, Matsuo O, Akagi M, Kaji H
  • Journal Title: Bone Volume: 79 Pages: 233-241
  • DOI: 10.1016/j.bone.2015.06.009
  • Peer Reviewed
• [Journal Article] Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. (2014)
  • Author(s): 毛莉、河尾直之、田村行識、奥本勝美、岡田 清孝、矢野昌人、松尾 理、梶 博史
  • Journal Title: PLoS One Volume: 20 Issue: 3 Pages: e92686-e92686
  • DOI: 10.1371/journal.pone.0092686
  • Peer Reviewed / Open Access
• [Presentation] ウロキナーゼ型プラスミノゲンアクチベーターはCCL3を介して骨修復過程早期のマクロファージ集積に関与する. (2015)
  • Author(s): 河尾直之、田村行識、堀内喜高、奥本勝美、矢野昌人、岡田清孝、松尾理、梶博史.
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2015-07-23
• [Presentation] 骨修復過程に誘導される骨髄幹細胞変化とSDF-1の役割. (2015)
  • Author(s): 岡田清孝、河尾直之、田村行識、矢野昌人、蔵下伸治、奥本勝美、児嶋耕太郎、梶博史.
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2015-07-23
• [Presentation] ステロイド性骨粗鬆症、糖尿病および筋萎縮の病態機序におけるPlasminogen Activator Inhibitor-1の役割. (2015)
  • Author(s): 田村行識、河尾直之、矢野昌人、岡田清孝、奥本勝美、千葉康敬、松尾理、梶博史.
  • Organizer: 第33回日本骨代謝学会学術集会
  • Place of Presentation: 東京（京王プラザホテル）
  • Year and Date: 2015-07-23
• [Presentation] Plasminogen Activator Inhibitor-1 Is Involved In Glucocorticoid-Induced Osteopenia, Diabetes And Muscle Wasting In Mice. (2015)
  • Author(s): Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H.
  • Organizer: 4th Joint Meeting of ECTS and IBMS
  • Place of Presentation: Rotterdam, Netherlands
  • Year and Date: 2015-04-25
  • Int'l Joint Research
• [Presentation] Plasminogen activator inhibitor-1は糖尿病による骨修復遅延に関与する。 (2014)
  • Author(s): 河尾直之、毛莉、田村行識、奥本勝美、岡田清孝、矢野昌人、松尾理、梶博史
  • Organizer: 第32回日本骨代謝学会学術集会
  • Place of Presentation: 大阪（大阪国際会議場）
  • Year and Date: 2014-07-24 – 2014-07-26
• [Remarks] 近畿大学医学部再生機能医学教室ホームページ
  • URL: http://www.med.kindai.ac.jp/physio2/