A physiological study of KCNQ channel functions in the mammalian cerebellum.
| Project/Area Number |
26860154
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General physiology
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| Research Institution | National Institute of Health Sciences |
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Principal Investigator |
Irie Tomohiko 国立医薬品食品衛生研究所, 薬理部, 主任研究官 (20546551)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | カリウムチャネル / 活動電位 / 神経細胞 / イオンチャネル |
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| Outline of Final Research Achievements |
Voltage gated potassium channels play crucial roles in excitable cells. KCNQ channels belong to the potassium channels and are expressed in the central nervous systems. However, little is known about the physiological roles. Electrophysiological recordings were done from cerebellar acute brain slice preparations. Application of a KCNQ channel blocker or opener reveals that KCNQ channels play roles in maintaining the membrane potential and neuronal excitabilities of cerebellar neurons, suggesting KCNQ channels contribute to the function of the motor coordination conveyed by the cerebellum.
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Report
(3 results)
Research Products
(7 results)
