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Identification of age-related molecules in the circadian clock

Research Project

Project/Area Number 26860160
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionMeiji University

Principal Investigator

NAKAMURA TAKAHIRO  明治大学, 農学部, 講師 (00581985)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords加齢 / 生体リズム / 睡眠障害 / 視交叉上核 / 概日リズム / 視床下部 / 神経回路
Outline of Final Research Achievements

With age, humans experience decreased duration and quality of sleep. While our group reported an age-related decline of the neuronal activity rhythms in the master circadian clock in the suprachiasmatic nucleus (SCN) of hypothalamus (Nakamura et al., J. Neurosci. 2011), the cellular mechanism was unclear. In the present study, we demonstrated an effect of aging at the cellular level. This shows that the neural connections between SCN cells are weakened (Nakamura et al., eNeuro 2015). Furthermore, our group reported that infertility symptoms accompanying aging are caused by which a light environment is incompatible with the biological clock (Takasu et al., Cell Rep. 2015). The result of the present research study, that “mismatch between the light environment and the internal clock promotes aging of the biological clock” shows proper amounts of daytime light are important for age-related changes in female reproductive functioning and older individuals’ physiological functioning.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (29 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (10 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results,  Open Access: 6 results,  Acknowledgement Compliant: 3 results) Presentation (15 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results) Remarks (3 results)

  • [Int'l Joint Research] University of California Los Angeles(米国)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] The suprachiasmatic nucleus: age-related decline in biological rhythms2016

    • Author(s)
      Nakamura TJ, Takasu NN, Nakamura W.
    • Journal Title

      J Physiol Sci.

      Volume: in press

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Single Neonatal Injection of Ethinyl Estradiol Impairs Passive Avoidance Learning and Reduces Expression of Estrogen Receptor α in the Hippocampus and Cortex of Adult Female Rats.2016

    • Author(s)
      Shiga T, Nakamura TJ, Komine C, Goto Y, Mizoguchi Y, Yoshida M, Kondo Y, Kawaguchi M.
    • Journal Title

      PLoS One

      Volume: 11 Issue: 1 Pages: e0146136-e0146136

    • DOI

      10.1371/journal.pone.0146136

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cryptochrome-dependent circadian periods in the arcuate nucleus.2016

    • Author(s)
      Uchida H, Nakamura TJ, Takasu NN, Todo T, Sakai T, Nakamura W.
    • Journal Title

      Neurosci Lett.

      Volume: 610 Pages: 123-128

    • DOI

      10.1016/j.neulet.2015.10.071

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Age-Related Changes in the Circadian System Unmasked by Constant Conditions2015

    • Author(s)
      Nakamura TJ, Nakamura W, Tokuda IT, Ishikawa T, Kudo T, Colwell CS, Block GD
    • Journal Title

      eNeuro

      Volume: 2 Issue: 4 Pages: ENEURO.0064-15.2015

    • DOI

      10.1523/eneuro.0064-15.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Recovery from age-related infertility under environmental light-dark cycles adjusted to the intrinsic circadian period.2015

    • Author(s)
      Takasu NN, Nakamura TJ, Tokuda IT, Todo T, Block GD, Nakamura W.
    • Journal Title

      Cell Rep.

      Volume: 12 Issue: 9 Pages: 1407-1413

    • DOI

      10.1016/j.celrep.2015.07.049

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015

    • Author(s)
      Yoshikuni Goto, Kenji Ogawa, Takahiro J Nakamura, Akira Hattori, Masafumi Tsujimoto
    • Journal Title

      Journal of Biochemistry

      Volume: 157 Issue: 6 Pages: 439-49

    • DOI

      10.1093/jb/mvv001

    • NAID

      40020489236

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Substrate-dependent nitric oxide synthesis by secreted endoplasmic reticulum aminopeptidase 1 in macrophages2015

    • Author(s)
      Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M.
    • Journal Title

      J Biochem.

      Volume: -

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TLR-Mediated Secretion of Endoplasmic Reticulum Aminopeptidase 1 from Macrophages2014

    • Author(s)
      Goto Y, Ogawa K, Nakamura TJ, Hattori A, Tsujimoto M.
    • Journal Title

      J Immunol

      Volume: 192 Issue: 9 Pages: 4443-4452

    • DOI

      10.4049/jimmunol.1300935

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 体内時計概論2014

    • Author(s)
      中村 孝博、中村 渉
    • Journal Title

      あたらしい眼科

      Volume: 31 Pages: 191-8

    • Related Report
      2014 Research-status Report
  • [Journal Article] 眼とブルーライト、体内時計2014

    • Author(s)
      坪田 一男、中村 孝博
    • Journal Title

      あたらしい眼科

      Volume: 31 Pages: 161-3

    • Related Report
      2014 Research-status Report
  • [Presentation] 視交叉上核:加齢の影響2016

    • Author(s)
      中村孝博
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] CBA亜系統における概日行動リズム特性2016

    • Author(s)
      伊藤寿々花、武井美澪、中野まりな、中村渉、下村和宏、中村孝博
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 性周期発現には視交叉上核からの神経時刻情報が必須である2016

    • Author(s)
      水田習斗、 大野琴美、中村渉、徳田功、中村孝博
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視交叉上核の外科的隔離が雌性マウスの性周期に及ぼす影響2016

    • Author(s)
      水田習斗、 大野琴美、中村渉、徳田功、中村孝博
    • Organizer
      第11回環境生理学プレコングレス
    • Place of Presentation
      北海道大学大学院医学研究科フラテ会館
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] CBA亜系統における概日リズムの亜系統差2016

    • Author(s)
      武井美澪、伊藤寿々花、中野まりな、中村渉、下村和宏、中村孝博
    • Organizer
      第11回環境生理学プレコングレス
    • Place of Presentation
      北海道大学大学院医学研究科フラテ会館
    • Year and Date
      2016-03-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] 視交叉上核からの神経投射は性周期を維持するために必須である2015

    • Author(s)
      水田習斗、 大野琴美、中村渉、中村孝博
    • Organizer
      22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] CBA亜系統における概日行動リズム特性2015

    • Author(s)
      伊藤寿々花、中野まりな、武井美澪、中村渉、下村和宏、中村孝博
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウス概日行動リズムの加齢変化と“社会的”時差ボケ2015

    • Author(s)
      高須奈々、中村孝博、草野慎之介、中西祐一郎、徳田功、中村渉
    • Organizer
      第22回日本時間生物学会学術大会
    • Place of Presentation
      東京大学本郷キャンパス
    • Year and Date
      2015-11-21
    • Related Report
      2015 Annual Research Report
  • [Presentation] he neural connection from suprachiasmatic nucleus is necessary for estrous cyclicity2015

    • Author(s)
      Shuto Mizuta, Kotomi Ohno, Wataru Nakamura, Takahiro J. Nakamura
    • Organizer
      Asian Forum on Chronobiology in 2015
    • Place of Presentation
      Sappro
    • Year and Date
      2015-09-07
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 雌ラットへの生後24時間以内のEE曝露が 大脳皮質と海馬のestrogen receptor(ER)α,β発現に及ぼす影響2015

    • Author(s)
      立川直之、志賀健臣、中村孝博、小峰千亜希、堀井康行、 渡辺元、田谷一善、溝口康、吉田緑、川口真以子
    • Organizer
      第62回 日本実験動物学会総会
    • Place of Presentation
      京都テルサ、京都市
    • Year and Date
      2015-05-28 – 2015-05-30
    • Related Report
      2014 Research-status Report
  • [Presentation] Aging Dissociates Circadian PER2 Oscillations of Individual Cells in the Suprachiasmatic Clock2015

    • Author(s)
      Nakamura TJ, Tokuda IT, Nakamuwa W, Ishikawa T, Kudo T, Colwell CS, Block GD
    • Organizer
      第92回日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場、神戸市
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Neonatal exposure to ethinyl estradiol decreased the learning performance and the expression levels of ER alpha in adult female rats2014

    • Author(s)
      Shiga T, Nakamura TJ, Mizoguchi Y, Komine C, Goto Y, Kamishima M, Kondo Y, Kawaguchi M
    • Organizer
      Neuroscience 2014
    • Place of Presentation
      Washington, DC, USA
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Aging Affects Circadian PER2 Oscillation of Individual Cell in the Suprachiasmatic Clock2014

    • Author(s)
      Nakamura TJ, Tokuda IT, Nakamuwa W, Ishikawa T, Kudo T, Colwell CS, Block GD
    • Organizer
      第21回日本時間生物学会学術大会
    • Place of Presentation
      九州大学、福岡市
    • Year and Date
      2014-11-07 – 2014-11-09
    • Related Report
      2014 Research-status Report
  • [Presentation] 卵巣ステロイドホルモンが概日リズムに与える影響2014

    • Author(s)
      中村 孝博
    • Organizer
      第67回日本自律神経学会
    • Place of Presentation
      ラフレ埼玉、さいたま市
    • Year and Date
      2014-10-30 – 2014-10-31
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 体内時計の光受容と反応性2014

    • Author(s)
      中村 渉、中村 孝博
    • Organizer
      第14回日本抗加齢医学会総会プレシンポジウム
    • Place of Presentation
      大阪国際会議場、大阪市
    • Year and Date
      2014-06-06 – 2014-06-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 明治大学農学部動物生理学研究室

    • URL

      http://www.isc.meiji.ac.jp/~chrono/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 明治大学教員データベース

    • URL

      http://gyoseki1.mind.meiji.ac.jp/mjuhp/KgApp?kojinId=140033

    • Related Report
      2015 Annual Research Report 2014 Research-status Report
  • [Remarks] researchmap

    • URL

      http://researchmap.jp/tjnakamura/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2022-01-27  

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