Identification of age-related molecules in the circadian clock
| Project/Area Number |
26860160
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 加齢 / 生体リズム / 睡眠障害 / 視交叉上核 / 概日リズム / 視床下部 / 神経回路 |
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| Outline of Final Research Achievements |
With age, humans experience decreased duration and quality of sleep. While our group reported an age-related decline of the neuronal activity rhythms in the master circadian clock in the suprachiasmatic nucleus (SCN) of hypothalamus (Nakamura et al., J. Neurosci. 2011), the cellular mechanism was unclear. In the present study, we demonstrated an effect of aging at the cellular level. This shows that the neural connections between SCN cells are weakened (Nakamura et al., eNeuro 2015). Furthermore, our group reported that infertility symptoms accompanying aging are caused by which a light environment is incompatible with the biological clock (Takasu et al., Cell Rep. 2015). The result of the present research study, that “mismatch between the light environment and the internal clock promotes aging of the biological clock” shows proper amounts of daytime light are important for age-related changes in female reproductive functioning and older individuals’ physiological functioning.
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Report
(3 results)
Research Products
(29 results)
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[Presentation] 体内時計の光受容と反応性2014
Author(s)
中村 渉、中村 孝博
Organizer
第14回日本抗加齢医学会総会プレシンポジウム
Place of Presentation
大阪国際会議場、大阪市
Year and Date
2014-06-06 – 2014-06-08
Related Report
Invited
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