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Study On Glucose Metabolism Via G-protein-Coupled Estrogen Receptor 1 Expression In The Hypothalamus

Research Project

Project/Area Number 26860162
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Fukushima Atsushi  聖マリアンナ医科大学, 医学部, 助教 (10442716)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsニューロペプチドY / GPER / エストロゲン / 視床下部 / GPR30 / G1 / G15 / Neuropeptide Y / 代謝 / 受容体
Outline of Final Research Achievements

The present study was carried out to see possible involvement of G-protein-coupled estrogen receptor 1 (GPER, GPR30) in NPY neurons to glucose metabolism. Rats were ovariectomized and were primed with the silicone tube containing cholesterol or GPER selective agonist G1. Firstly, we revealed that G1 agonist did not have estrogenic action in reproductive system. Glucose tolerance test was worsened by G1 treatment in rats. In high fat fed mice, glucose tolerance was affected by G1 dose depending manner. These results suggested that GPER affect glucose metabolism in a manner different from via estrogen receptor-α and through NPY neurons. Since NPY neurons were identified by mVenus under fluorescent microscopy and this transgenic mice were expressed the human interleukin 2 receptor alpha subunit (IL-2R alpha) under the control of the NPY gene promoter. Thus treatment immunotoxin ablates conditionally NPY neurons.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2016 2015 2014

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (12 results)

  • [Journal Article] Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus.2015

    • Author(s)
      Fukushima A, Hagiwara H, Fujioka H, Kimura F, Akema T, Funabashi T.
    • Journal Title

      Front Neurosci.

      Volume: 88 Pages: 1-7

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Ketogenic diet does not impair spatial ability controlled by the hippocampus in male rats.2015

    • Author(s)
      Fukushima A, Ogura Y, Furuta M, Kakehashi C, Funabashi T, Akema T.
    • Journal Title

      Brain Res.

      Volume: 1622 Pages: 36-42

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sex differences in feeding behavior in rats: the relationship with neuronal activation in the hypothalamus.2015

    • Author(s)
      Fukushima A, Hagiwara H, Fujioka H, Kimura F, Akema T, Funabashi T.
    • Journal Title

      Front Neurosci

      Volume: 9 Pages: 1-8

    • DOI

      10.3389/fnins.2015.00088

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of phosphorylated cyclic AMP response element-binding protein in melanin-concentrating hormone neurons and orexin neurons in male and female rats during ad-libitum feeding2014

    • Author(s)
      Fukushima A, Hagiwara H, Yoshioka N, Kimura F, Akema T, Funabashi T
    • Journal Title

      Neuroreport.

      Volume: 25 Issue: 10 Pages: 766-770

    • DOI

      10.1097/wnr.0000000000000172

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hepatic oxidative stress promotes insulin-STAT-5 signaling and obesity by inactivating protein tyrosine phosphatase N2.2014

    • Author(s)
      Gurzov EN, Tran M, Fernandez-Rojo MA, Merry TL, Zhang X, Xu Y, Fukushima A, Waters MJ, Watt MJ, Andrikopoulos S, Neel BG, Tiganis T.
    • Journal Title

      Cell Metabolism

      Volume: 20 Issue: 1 Pages: 85-102

    • DOI

      10.1016/j.cmet.2014.05.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 雌性ラットの幼弱期ニコチン投与ならびに母性行動が成体期の母性行動および空間学習に及ぼす影響2016

    • Author(s)
      Miyako Furuta, Atsushi Fukushima, Tatsuo Akema, Toshiya Funabashi
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] ミノサイクリンはリポポリサッカライドによるLHパルス状分泌抑制を回復しない。2016

    • Author(s)
      Hitomi Fujioka, Atsushi Fukushima, Toshiya Funabashi, Tatsuo Akema
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 血小板由来成長因子はマウスの視床下部による摂食調節に関与する2016

    • Author(s)
      Hiroko Hagiwara, Atsushi Fukushima, Tatsuo Akema, Toshiya Funabashi
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 肝臓のPDGFRa系を介したSTAT5のリン酸化は高脂肪食による肥満と糖耐性の低下に関与する2016

    • Author(s)
      Atsushi Fukushima, Hiroko Hagiwara, Tatsuo Akema, Toshiya Funbashi
    • Organizer
      第93回日本生理学会
    • Place of Presentation
      札幌コンベンションセンター (北海道・札幌市)
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 妊娠、出産、子育て経験後の学習機能の向上とAMPA受容体サブユニットの構成の変化2015

    • Author(s)
      古田 都、福島 篤、舩橋 利也、明間 立雄
    • Organizer
      第42回日本神経内分泌学会学術集会,第23回日本行動神経内分泌研究会
    • Place of Presentation
      仙台市戦災復興記念館 (宮城県・仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] エストロジェンによる摂食調節は視床下部のオリゴデンドロサイト前駆細胞のPDGFRαを介する2015

    • Author(s)
      萩原裕子, 福島篤, 舩橋利也, 明間立雄
    • Organizer
      第42回日本神経内分泌学会学術集会,第23回日本行動神経内分泌研究会
    • Place of Presentation
      仙台市戦災復興記念館 (宮城県・仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 絶食によりマウス視床下部のオリゴデンドロサイト前駆細胞のPDGFRaを介したシグナルは刺激されるが、高脂肪食によりこの調節系が障害される2015

    • Author(s)
      福島 篤, 萩原 裕子, 舩橋 利也, 明間 立雄
    • Organizer
      第42回日本神経内分泌学会学術集会,第23回日本行動神経内分泌研究会
    • Place of Presentation
      仙台市戦災復興記念館 (宮城県・仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Annual Research Report
  • [Presentation] 妊娠-出産-子育て後の海馬の神経可塑性と空間学習への影響2015

    • Author(s)
      Miyako Furuta, Atsushi Fukushima, Toshiya Funabashi, Tatsuo Akema
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場 (兵庫県・神戸市)
    • Year and Date
      2015-07-29
    • Related Report
      2015 Annual Research Report
  • [Presentation] 絶食によりマウス視床下部のオリゴデンドロサイト前駆細胞のPDGFRα を介したシグナルは刺激されるが、高脂肪食によりこの調節系が障害される2015

    • Author(s)
      福島篤、萩原裕子、母家真祐子、舩橋利也、明間立雄
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸国際会議場 (兵庫県・神戸市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 絶食時に視床下部のミクログリアがPDGFR-aを介して摂食調節に関与する仮説2014

    • Author(s)
      福島篤、萩原裕子、藤岡仁美、舩橋利也、明間立雄
    • Organizer
      第41回日本神経内分泌学会
    • Place of Presentation
      都道府県会館 (東京都・千代田区)
    • Year and Date
      2014-10-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Study on Glucose Metabolism via G-Protein-Coupled Estrogen Receptor 1 Expression In The Hypothalamus2014

    • Author(s)
      Atsushi Fukushima, Toshiya Funabashi, Tatsuo Akema
    • Organizer
      8th International Congress of Neuroendocrinology
    • Place of Presentation
      Sydney (Australia)
    • Year and Date
      2014-08-18
    • Related Report
      2014 Research-status Report
  • [Presentation] エストロゲンの細胞膜エス トロゲン受容体GPERを介し た摂食調節機構に関する研 究2014

    • Author(s)
      福島篤、舩橋利也、古田都、藤岡仁美 、小倉裕司、明間立雄
    • Organizer
      第32回内分泌代謝学 サマーセミナー
    • Place of Presentation
      富士レークホテル (山梨県・都留郡)
    • Year and Date
      2014-07-11
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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