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Is hypertension due to sleep apnea caused by hyperactivation of sympathetic nervous activity?

Research Project

Project/Area Number 26860165
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Environmental physiology(including physical medicine and nutritional physiology)
Research InstitutionNara Women's University

Principal Investigator

YOSHIMOTO MISA  奈良女子大学, 生活環境科学系, 准教授 (20418784)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords睡眠時無呼吸症候群 / 高血圧 / 神経性動脈圧調節 / 腎交感神経活動 / ラット / 腰部交感神経活動 / 動脈圧 / 腎交感神経 / 腰部交感神経 / 間歇的低酸素暴露
Outline of Final Research Achievements

Sleep apnea syndrome (SAS) is complicated by cardiovascular diseases. Activation of sympathetic nerve activity has been suggested to contribute the cardiovascular diseases, while there has been little direct evidence on sympathetic nerve activity (SNA). We measured directly response of SNA to elucidate causal linkage between hypertension and activation of SNA in response to SAS. To simulate SAS in rats, Intermittent hypoxia (IH) and a balloon implanted in the trachea induction of apnea.
Arterial pressure (AP) and renal SNA (RSNA) increased immediately after the onset of exposed 5% IH every time, but baselines did not change. While, AP and RSNA increased immediately after the onset of the obstruction and baseline of RSNA increase day bay day.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (13 results)

All 2017 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (9 results)

  • [Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016

    • Author(s)
      Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
    • Journal Title

      Am J Physiol Regul Integr Comp Physiol.

      Volume: 311(2) Issue: 2 Pages: 426-439

    • DOI

      10.1152/ajpregu.00112.2016

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Monoamine oxidase-induced hydroxyl radical production and cardiomyocyte injury during myocardial ischemia-reperfusion in rats2016

    • Author(s)
      Tadakatsu Inagaki, Tsuyoshi Akiyama, Cheng-Kun Du, Dong-Yun Zhan, Misa Yoshimoto & Mikiyasu Shirai
    • Journal Title

      Free Radical Research

      Volume: 50 Issue: 6 Pages: 645-653

    • DOI

      10.3109/10715762.2016.1162300

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia2014

    • Author(s)
      Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James T. Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl O. Schwenke
    • Journal Title

      Basic Research in Cardiology

      Volume: 109(5) Pages: 432-441

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of cardiac sympathetic nerves in blood pressure regulation2014

    • Author(s)
      Erica A. Wehrwein, Misa Yoshimoto, Pilar Guzman, Amit Shah, David L. Kreulen, John W. Osborn,
    • Journal Title

      Autonomic Neuroscience

      Volume: 183 Pages: 30-35

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 交感神経活動がDOCA-食塩高血圧発症に果たす役割2017

    • Author(s)
      吉本光佐、志波侑希、瀬戸口詩織、河村紫穂、三木健寿
    • Organizer
      日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] スボレキサントが恐怖条件ラットの海馬CA1神経活動と交感神経活動の変化2017

    • Author(s)
      長尾佳奈、浮田紘香、吉本光佐、三木健寿
    • Organizer
      日本生理学会大会
    • Place of Presentation
      アクトシティ浜松
    • Year and Date
      2017-03-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] 肺伸展受容器が閉塞性睡眠時無呼吸時の心拍数と交感神経活動調節に及ぼす影響2016

    • Author(s)
      吉本光佐
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-23
    • Related Report
      2015 Research-status Report
  • [Presentation] 慢性間歇的低酸素はインスリン抵抗性若年 Goto-Kakizaki ラットにおける冠微小循環障害を早める2016

    • Author(s)
      Pearson James, Chen Yiching, Inagaki Tadakatsu, Fujii Yutaka, Schwenke Daryl, Edgley Amanda, Umetani Keiji, Zhang Yuan, Yoshimoto Misa, Tsuchimochi Hirotsugu, Nagai Hisashi, Kuwahira Ichiro, Evans Roger, Shirai Mikiyasu
    • Organizer
      第93回日本生理学会大会
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2016-03-22
    • Related Report
      2015 Research-status Report
  • [Presentation] Zucker 肥満ラットにおいて交感神経活動が動脈圧上昇に果たす役割2015

    • Author(s)
      志波侑希,吉本光佐,三木健寿
    • Organizer
      第 54 回日本生気象学会大会
    • Place of Presentation
      中京大学名古屋キャンパス
    • Year and Date
      2015-11-06
    • Related Report
      2015 Research-status Report
  • [Presentation] Relationship between hippocampal CA1 neuronal and sympathetic nerve activity during fear conditioning in rats2015

    • Author(s)
      Misa Yoshimoto, Misaki Kanayama, Miki Kenjyu
    • Organizer
      Experimental Biology 2015
    • Place of Presentation
      Boston
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Research-status Report
  • [Presentation] Sympathetic nerve activity and arterial pressure during development of obesity in Zucker fatty rat2015

    • Author(s)
      Yuki Shiwa, Misa Yoshimoto, Miki Kenjyu
    • Organizer
      Experimental Biology 2015
    • Place of Presentation
      Boston
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 恐怖条件づけ過程における海馬CA1 神経活動と交感活動の変化2015

    • Author(s)
      喜多村有香、金山美紗貴、吉本光佐、三木健寿
    • Organizer
      第92回 日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
  • [Presentation] Zucker fatty rat の肥満発症時における交感神経活動と動脈圧の変化2015

    • Author(s)
      志波侑希、岡野里香、吉本光佐、三木健寿
    • Organizer
      第92回 日本生理学会大会
    • Place of Presentation
      神戸国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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