| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Outline of Final Research Achievements |
Sleep apnea syndrome (SAS) is complicated by cardiovascular diseases. Activation of sympathetic nerve activity has been suggested to contribute the cardiovascular diseases, while there has been little direct evidence on sympathetic nerve activity (SNA). We measured directly response of SNA to elucidate causal linkage between hypertension and activation of SNA in response to SAS. To simulate SAS in rats, Intermittent hypoxia (IH) and a balloon implanted in the trachea induction of apnea.
Arterial pressure (AP) and renal SNA (RSNA) increased immediately after the onset of exposed 5% IH every time, but baselines did not change. While, AP and RSNA increased immediately after the onset of the obstruction and baseline of RSNA increase day bay day.
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