Is hypertension due to sleep apnea caused by hyperactivation of sympathetic nervous activity?
Project/Area Number |
26860165
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Environmental physiology(including physical medicine and nutritional physiology)
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Research Institution | Nara Women's University |
Principal Investigator |
YOSHIMOTO MISA 奈良女子大学, 生活環境科学系, 准教授 (20418784)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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Keywords | 睡眠時無呼吸症候群 / 高血圧 / 神経性動脈圧調節 / 腎交感神経活動 / ラット / 腰部交感神経活動 / 動脈圧 / 腎交感神経 / 腰部交感神経 / 間歇的低酸素暴露 |
Outline of Final Research Achievements |
Sleep apnea syndrome (SAS) is complicated by cardiovascular diseases. Activation of sympathetic nerve activity has been suggested to contribute the cardiovascular diseases, while there has been little direct evidence on sympathetic nerve activity (SNA). We measured directly response of SNA to elucidate causal linkage between hypertension and activation of SNA in response to SAS. To simulate SAS in rats, Intermittent hypoxia (IH) and a balloon implanted in the trachea induction of apnea. Arterial pressure (AP) and renal SNA (RSNA) increased immediately after the onset of exposed 5% IH every time, but baselines did not change. While, AP and RSNA increased immediately after the onset of the obstruction and baseline of RSNA increase day bay day.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Chronic intermittent hypoxia accelerates coronary microcirculatory dysfunction in insulin-resistant Goto-Kakizaki rats.2016
Author(s)
Chen YC, Inagaki T, Fujii Y, Schwenke DO, Tsuchimochi H, Edgley AJ, Umetani K, Zhang Y, Kelly DJ, Yoshimoto M, Nagai H, Evans RG, Kuwahira I, Shirai M, Pearson JT.
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Journal Title
Am J Physiol Regul Integr Comp Physiol.
Volume: 311(2)
Issue: 2
Pages: 426-439
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Pulmonary vascular tone is dependent on the central modulation of sympathetic nerve activity following chronic intermittent hypoxia2014
Author(s)
Mikiyasu Shirai, Hirotsugu Tsuchimochi, Hisashi Nagai, Emily Gray, James T. Pearson, Takashi Sonobe, Misa Yoshimoto, Tadakatsu Inagaki, Yutaka Fujii, Keiji Umetani, Ichiro Kuwahira, Daryl O. Schwenke
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Journal Title
Basic Research in Cardiology
Volume: 109(5)
Pages: 432-441
Related Report
Peer Reviewed
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[Presentation] 慢性間歇的低酸素はインスリン抵抗性若年 Goto-Kakizaki ラットにおける冠微小循環障害を早める2016
Author(s)
Pearson James, Chen Yiching, Inagaki Tadakatsu, Fujii Yutaka, Schwenke Daryl, Edgley Amanda, Umetani Keiji, Zhang Yuan, Yoshimoto Misa, Tsuchimochi Hirotsugu, Nagai Hisashi, Kuwahira Ichiro, Evans Roger, Shirai Mikiyasu
Organizer
第93回日本生理学会大会
Place of Presentation
札幌コンベンションセンター
Year and Date
2016-03-22
Related Report
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