Activation of HIF by inhibiting FIH: the development of novel organic molecules inhibiting FIH selectively
| Project/Area Number |
26860168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General pharmacology
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| Research Institution | Saga University (2015-2016)
Tohoku University (2014) |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | HIF / 低酸素誘導因子 / FIH / 低分子阻害剤 / 構造活性相関 / 低分子化合物 / ドッキングシミュレーション / 虚血性疾患治療薬 |
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| Outline of Final Research Achievements |
In this study, the exploration of novel organic molecules inhibiting FIH (Factor Inhibiting HIF) was conducted because previous studies shows that HIF (hypoxia inducible factor: transcription factor) can be gently activated by inhibiting FIH. The gentle activation of HIF is effective for the treatment of ischemic disease. The research group synthesized about 70 compounds and a few compounds of them induced gentle activation of HIF.
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Report
(4 results)
Research Products
(7 results)
