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Analysis of a novel stress response system exerting neuroprotective effects

Research Project

Project/Area Number 26860178
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionHirosaki University

Principal Investigator

YAMAZAKI Hiromi  弘前大学, 医学(系)研究科(研究院), 助教 (20720915)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアミノ酸飢餓 / 酸化ストレス / GCN1 / Nrf2
Outline of Final Research Achievements

In this study, we analyzed GCN1 knockout mice to reveal a role of amino acid starvation responsive factor GCN1. GCN1 knockout mice exhibited growth retardation after E11.5 and died of respiratory failure after birth. We previously found that oxidative stress responsive factor Nrf2 binds to GCN1, and we further clarified that GCN1 is essential for expression of Nrf2 target gene, heme oxygenase-1. Collectively, we showed that GCN1 is indispensable for mice embryogenesis and GCN1 and Nrf2 cooperatively contribute to stress response.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (4 results)

All 2015 2014 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (1 results)

  • [Journal Article] Role of the Keap1/Nrf2 pathway in neurodegenerative diseases.2015

    • Author(s)
      Yamazaki H, Tanji K, Wakabayashi K, Matsuura S, Itoh K.
    • Journal Title

      Pathol Int

      Volume: 65 Issue: 5 Pages: 210-9

    • DOI

      10.1111/pin.12261

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Remote GATA2 Hematopoietic Enhancer Drives Leukemogenesis in inv(3)(q21 ; q26) by Activating EVI1 Expression2014

    • Author(s)
      Yamazaki H, Suzuki M, Otsuki A, Shimizu R, Bresnick EH, Engel JD, Yamamoto M.
    • Journal Title

      Cancer Cell

      Volume: 25 Issue: 4 Pages: 415-427

    • DOI

      10.1016/j.ccr.2014.02.008

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Screening of mitophagy inducers in HeLa cells.2015

    • Author(s)
      Yamazaki H, Mimura J, Itoh K.
    • Organizer
      6th world congress on targeting mitochondria
    • Place of Presentation
      Berlin Germany
    • Year and Date
      2015-10-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Remarks] ライフサイエンス新着論文レビュー

    • URL

      http://first.lifesciencedb.jp/archives/8631

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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