Research Project
Grant-in-Aid for Young Scientists (B)
Erythropoietin (EPO) is a humoral factor potentiating erythropoiesis. EPO expression was strictly regulated by oxygen level in vivo. Recent studies revealed that Epo expression is repressed by GATA transcription factors in a part of epithelial tissues in vivo. In this study, I utilized genetic and pharmacological approach to inhibit the function of GATA factors and elucidated that disturbance of GATA factors resulted in the release of Epo expression from non-canonical EPO producing cells. These evidences clearly demonstrated the validity of GATA factors as novel therapeutic target of renal anemia.
All 2015
All Presentation (2 results) Patent(Industrial Property Rights) (1 results)
