Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral Signaling
| Project/Area Number |
26860181
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
General medical chemistry
|
|---|
| Research Institution | Tohoku University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2016-03-31
|
| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | Ral / 低分子量GTP結合蛋白質 / Ras / RalGAP / 癌 / 低分子量GTP結合タンパク質 |
|---|
| Outline of Final Research Achievements |
Ral proteins are members of the Ras superfamily of small GTP-binding proteins that regulate many cellular processes including proliferation, survival, membrane traffic, and cytoskeletal reorganization. Accumulating evidence suggests that Ral is essential for human tumorigenesis and tumor progression. However, its molecular mechanism is largely unknown. In this study we purified and identified novel effector proteins of Ral that may regulate tumorigenesis, invasion, and metastasis.
|
Report
(3 results)
Research Products
(10 results)
-
-
-
-
-
[Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension (CTEPH).2014
Author(s)
Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
-
Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 34
Issue: 11
Pages: 2486-2494
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
-
[Journal Article] GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins2014
Author(s)
Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S
-
Journal Title
Cellular Signalling
Volume: 26
Issue: 8
Pages: 1636-1648
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
-
