| Project/Area Number |
26860181
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Ral / 低分子量GTP結合蛋白質 / Ras / RalGAP / 癌 / 低分子量GTP結合タンパク質 |
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| Outline of Final Research Achievements |
Ral proteins are members of the Ras superfamily of small GTP-binding proteins that regulate many cellular processes including proliferation, survival, membrane traffic, and cytoskeletal reorganization. Accumulating evidence suggests that Ral is essential for human tumorigenesis and tumor progression. However, its molecular mechanism is largely unknown. In this study we purified and identified novel effector proteins of Ral that may regulate tumorigenesis, invasion, and metastasis.
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