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Analysis of Tumorigenesis and Malignant Transformation Induced by Aberrant Ral Signaling

Research Project

Project/Area Number 26860181
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionTohoku University

Principal Investigator

Shirakawa Ryutaro  東北大学, 加齢医学研究所, 助教 (50581039)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsRal / 低分子量GTP結合蛋白質 / Ras / RalGAP / 癌 / 低分子量GTP結合タンパク質
Outline of Final Research Achievements

Ral proteins are members of the Ras superfamily of small GTP-binding proteins that regulate many cellular processes including proliferation, survival, membrane traffic, and cytoskeletal reorganization. Accumulating evidence suggests that Ral is essential for human tumorigenesis and tumor progression. However, its molecular mechanism is largely unknown. In this study we purified and identified novel effector proteins of Ral that may regulate tumorigenesis, invasion, and metastasis.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (10 results)

All 2016 2015 2014 Other

All Journal Article (7 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 7 results,  Open Access: 1 results) Presentation (1 results) Remarks (2 results)

  • [Journal Article] Prostaglandin E2 inhibits neutrophil extracellular trap formation through production of cyclic AMP2016

    • Author(s)
      3.K. Shishikura, T. Horiuchi, N. Sakata, D-A Trinh, R. Shirakawa, T. Kimura, Y. Asada, H. Horiuchi*
    • Journal Title

      Br J Pharmacol

      Volume: 173 Issue: 2 Pages: 319-331

    • DOI

      10.1111/bph.13373

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis.2015

    • Author(s)
      Shirakawa R, Horiuchi H.
    • Journal Title

      The Journal of Biochemistry

      Volume: 157 Issue: 5 Pages: 285-299

    • DOI

      10.1093/jb/mvv029

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Ral GTPases: crucial mediators of exocytosis and tumourigenesis2015

    • Author(s)
      Shirakawa R, Horiuchi H
    • Journal Title

      The Journal of Biochemistry

      Volume: 印刷中

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Identification of RalGAPs and their downregulation in invasive bladder cancer2014

    • Author(s)
      Shirakawa R, Horiuchi H
    • Journal Title

      Seikagaku

      Volume: 86 Pages: 671-675

    • NAID

      40020254531

    • Related Report
      2014 Research-status Report
    • Acknowledgement Compliant
  • [Journal Article] Platelets are highly activated in patients of chronic thromboembolic pulmonary hypertension2014

    • Author(s)
      Yaoita N, Shirakawa R, Fukumoto Y, Sugimura K, Miyata S, Miura Y, Nochioka K, Miura M, Tatebe S, Aoki T, Miyamichi-Yamamoto S, Satoh K, Kimura T, Shimokawa H, Horiuchi H.
    • Journal Title

      Arterioscler Thromb Vasc Biol.

      Volume: 34 Issue: 11 Pages: 2486

    • DOI

      10.1161/atvbaha.114.304404

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] The antimalarial drugs chloroquine and primaquine inhibit pyridoxal kinase, an essential enzyme for vitamin B6 production2014

    • Author(s)
      Kimura T, Shirakawa R, Yaoita N, Hayashi T, Nagano K, Horiuchi H
    • Journal Title

      FEBS letters

      Volume: 588 Issue: 20 Pages: 3673-3676

    • DOI

      10.1016/j.febslet.2014.08.011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] GARNL1, a major RalGAP α subunit in skeletal muscle, regulates insulin-stimulated RalA activation and GLUT4 trafficking via interaction with 14-3-3 proteins2014

    • Author(s)
      Chen Q, Quan C, Xie B, Chen L, Zhou S, Toth R, Campbell DG, Lu S, Shirakawa R, Horiuchi H, Li C, Yang Z, MacKintosh C, Wang HY, Chen S
    • Journal Title

      Cellular Signalling

      Volume: 26 Issue: 8 Pages: 1636-1648

    • DOI

      10.1016/j.cellsig.2014.04.012

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Presentation] プロスタグランジンE2はサイクリックAMP産生を介してNETs形成を阻害する2015

    • Author(s)
      木村朋寛、宍倉匡祐、堀内嵩弘、坂田菜摘、Trinh Duc-Anh、白川龍太郎、堀内久徳
    • Organizer
      日本分子生物学会日本生化学会合同大会
    • Place of Presentation
      神戸ポートアイランド(兵庫県・神戸市)
    • Year and Date
      2015-12-02
    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所基礎加齢研究分野

    • URL

      http://www2.idac.tohoku.ac.jp/dep/mcb/index.html

    • Related Report
      2015 Annual Research Report
  • [Remarks] 東北大学加齢医学研究所(堀内研究室)ホームページ

    • URL

      http://www2.idac.tohoku.ac.jp/dep/mcb/index.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2017-05-10  

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