| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Outline of Final Research Achievements |
The aim of this study was to identify bone-derived factor(s) that affect the body and to examine whether the effect was related to the condition of the bone (e.g. sex, age, health condition etc.). First, Igf1 was identified as an osteoblast lineage cell-secreted protein that induces neurite-like structures in cultured cells. Next, to study the physiological effect of Igf1, a genetically-modified mouse that do not produce Igf1 in osteoblasts was generated. Furthermore, a method to estimate bone innervation using mice that express fluorescent proteins in neurons was established. Further studies combining the Igf1 conditional knockout mice and the neuron-labeled mice are required to examine whether the loss of osteoblast-derived Igf1 affects bone innervation.
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