Analysis of the molecular pathology of frequently-accompanied pulmonary cancer in fibrotic lung
Project/Area Number |
26860185
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
General medical chemistry
|
Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Maruyama Junichi 東京医科歯科大学, 大学院医歯学総合研究科, 助教 (30723639)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 肺線維症 / 肺癌 / DNA損傷修復 / 癌転移 |
Outline of Final Research Achievements |
The molecular mechanism how idiopathic pulmonary fibrosis (IPF) is often accompanied by lung cancer is not fully understood. To address this question, I re-analyzed the GEO gene expression data obtained from IPF lung samples and identified DCLK1 as an up-regulated gene in the IPF lung. DCLK1 has been reported as a marker gene of cancer stem cells. I revealed that DCLK1 suppresses the activity of DNA repairing system and that DCLK1 protein expression level is up-regulated by the treatment of macrophage-like cell-conditioned medium. Taken together, it is suggested that the up-regulation of DCLK1 protein amount in the lung facilitates tumorigenesis and that this up-regulation can be promoted by the accumulation of macrophage cells in the lung.
|
Report
(4 results)
Research Products
(7 results)
-
-
-
-
[Journal Article] A cell-based screening for TAZ activators identifies ethacridine, a widely used antiseptic and abortifacient, as a compound that promotes dephosphorylation of TAZ and inhibits adipogenesis in C3H10T1/2 cells.2015
Author(s)
Kawano S, Maruyama J, Nagashima S, Inami K, Qiu W, Iwasa H, Nakagawa K, Ishigami-Yuasa M, Kagechika H, Nishina H, Hata Y.
-
Journal Title
J. Biochem.
Volume: 158
Issue: 5
Pages: 413-423
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
-
[Journal Article] A new cell-based assay to evaluate myogenesis in mouse myoblast C2C12 cells2015
Author(s)
Kodaka, M.; Yang, Z.; Nakagawa, K.; Maruyama, J.; Xu, X.; Sarkar, A.; Ichimura, A.; Nasu, Y.; Ozawa, T.; Iwasa, H.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, Y.
-
Journal Title
Exp. Cell. Res.
Volume: 336
Issue: 2
Pages: 171-181
DOI
Related Report
Peer Reviewed
-
[Journal Article] Screening with a Novel Cell-Based Assay for TAZ Activators Identifies a Compound That Enhances Myogenesis in C2C12 Cells and Facilitates Muscle Repair in a Muscle Injury Model.2014
Author(s)
Yang, Z. Y.; Nakagawa, K.; Sarkar, A.; Maruyama, J.; Iwasa, H.; Bao, Y. J.; Ishigami-Yuasa, M.; Ito, S.; Kagechika, H.; Hata, S.; Nishina, H.; Abe, S.; Kitagawa, M.; Hata, Y.
-
Journal Title
Mol. Cell. Biol.
Volume: 34
Issue: 9
Pages: 1607-1621
DOI
Related Report
Peer Reviewed / Open Access
-