| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
The molecular mechanism how idiopathic pulmonary fibrosis (IPF) is often accompanied by lung cancer is not fully understood. To address this question, I re-analyzed the GEO gene expression data obtained from IPF lung samples and identified DCLK1 as an up-regulated gene in the IPF lung. DCLK1 has been reported as a marker gene of cancer stem cells. I revealed that DCLK1 suppresses the activity of DNA repairing system and that DCLK1 protein expression level is up-regulated by the treatment of macrophage-like cell-conditioned medium. Taken together, it is suggested that the up-regulation of DCLK1 protein amount in the lung facilitates tumorigenesis and that this up-regulation can be promoted by the accumulation of macrophage cells in the lung.
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