Analysis of novel transcription regulation mechanism of glyoxalase 1
| Project/Area Number |
26860187
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
Harashima Ai 金沢大学, 医学系, 助教 (50705522)
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 転写調節 |
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| Outline of Final Research Achievements |
A gene polymorphism in human glyoxalase 1 (GLO1) promoter region was newly identified and was found to significantly induce transcriptional expression of the GLO1 gene. The gene polymorphism was also positively correlated with the GLO1 enzyme activity. Furthermore, we identified associated proteins with the GLO1 gene polymorphism in the nuclear extracts, which is essential for transcriptional upregulation of GLO1 gene. Taken together, these results suggested that epigenetic regulation could play an important role in human GLO1 gene expression.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination.2015
Author(s)
Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T.
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Journal Title
Gastric Cancer
Volume: 18
Issue: 4
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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