| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Age-related tissue stem cell dysfunctions should contribute to the disruption of tissue homeostasis and subsequent pathologies. It has been reported that some kind of systemic factors in young mice have effects to ameliorate age-related inefficient muscle repair due to restoration of regenerative capacity of aged muscle satellite cells. Some of other tissue stem/progenitor cells also restored proliferation in heterochronically connected old mice. However, little is known about the homeostatic factors and the mechanisms underlying its regenerative effects.
Recently, we identified Gdf6/Bmp13 as a homeostatic factor derived from young mesenchymal stem/stromal cells (MSCs). Administration of Gdf6 was restored the muscle wound healing and was increased neural precursor cells in a wide range from the subventricular zone to the striatum than control aged mice.
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