| Project/Area Number |
26860209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 軸索再生 / オートファジー / チロシンフォスファターゼ / 神経科学 / コンドロイチン硫酸 / へパラン硫酸 / ケラタン硫酸 |
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| Outline of Final Research Achievements |
Heparan sulfate and chondroitin sulfate are sulfated glycans which are involved in axonal elongation in our central nervous system. Although they share the same neuronal receptor PTPσ, how they differentially regulate it is still unknown. Here, minimum essential structures of heparan sulfate and chondroitin sulfate were successfully identified. In both glycans, tetrasaccharide is the shortest structure to interact with PTPσ. However, interestingly, the probability of the structures is quite rare in chondroitin sulfate, while quite rich in heparan sulfate. These findings account for how heparan sulfate and chondroitin sulfate work in opposing manner on PTPσ and axonal elongation.
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