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Biological activity of galectin-4 and its roles in colorectal cancer and normal tissue.

Research Project

Project/Area Number 26860213
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionKagawa University

Principal Investigator

Ogawa Takashi  香川大学, 医学部, 助教 (80405018)

Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsガレクチン / 大腸がん / 消化管 / レクチン / 腸 / ツメガエル / CRISPR
Outline of Final Research Achievements

Galectin-4 is a major galectin isoform existed in the digestive tract, and it may contribute to the differentiation of epithelial cell. Recently, many immunohistochemical studies have shown that the galectin-4 is highly expressed in normal tissues, but decreased in the adenoma and the invasion front of colonic cancers. These facts suggest that the galectin-4 has specific activity, which might be involved in tumor suppression. However, the direct correlation between disappearance of galectin-4 and its molecular mechanism of tumor inhibition remain to be understood. To investigate the role of galectin-4 in tumor growth, we prepared the stable transfectants of galectin-4 in human colonic cancer cells (CRCs). Then, we found that overexpression of the galectin-4 suppresses growth of CRCs. Furthermore, knockdown of galectin-4 resulted in an increased CRCs proliferation. These results suggest that galectin-4 contributes to the suppression of colorectal cancer.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2014

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Cooperative interactions of oligosaccharide and peptide moieties of a glycopeptide derived from IgE with galectin-92016

    • Author(s)
      Nakakita, S.-I., Itoh, A., Nakakita, Y., Nonaka, Y., Ogawa, T., Nakamura, T., Nishi, N.
    • Journal Title

      J. Biol. Chem.

      Volume: 291 Issue: 2 Pages: 968-979

    • DOI

      10.1074/jbc.m115.694448

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 1)Crystal structure of a Xenopus laevis skin proto-type galectin, close to but distinct from galectin-12015

    • Author(s)
      Nonaka Y, Ogawa T, Yoshida H, Shoji H, Nishi N, Kamitori S, Nakamura T
    • Journal Title

      Glycobiology

      Volume: 25 Pages: 792-803

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Crystal structure of a Xenopus laevis skin proto-type galectin, close to but distinct from galectin-12015

    • Author(s)
      Nonaka Y, Ogawa T, Yoshida H, Shoji H, Nishi N, Kamitori S, Nakamura T
    • Journal Title

      Glycobiology

      Volume: 印刷中 Issue: 7 Pages: 792-803

    • DOI

      10.1093/glycob/cwv020

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] Functional and expression analysis of Galectin-4 in Xenopus digestive tract and human colon carcinoma2015

    • Author(s)
      小川 崇,東海林 博樹,野中 康宏, 舘野 浩章, 平林 淳, 西 望,中村 隆範
    • Organizer
      BMB2015(第38回日本分子生物学会年会、第88回日本生化学会大会 合同大会)
    • Place of Presentation
      神戸ポートアイランド
    • Year and Date
      2015-12-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] 大腸がんにおけるガレクチン4の役割2015

    • Author(s)
      Takashi Ogawa
    • Organizer
      第74回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2015-10-08
    • Related Report
      2015 Annual Research Report
  • [Presentation] ツメガエル消化管およびヒト大腸がん細胞におけるガレクチン4の発現及び機能解析2014

    • Author(s)
      小川 崇,東海林 博樹,野中 康宏, 舘野 浩章, 平林 淳, 西 望,中村 隆範
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      京都
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Research-status Report
  • [Presentation] Biological activity of galectin-4 and its roles in CRCs growth.2014

    • Author(s)
      Takashi Ogawa
    • Organizer
      第73回日本癌学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-25 – 2014-09-27
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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