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Effects of fetal gene reprogramming on expression, distribution and expression of gap junction in failing hearts

Research Project

Project/Area Number 26860215
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pathological medical chemistry
Research InstitutionOita University

Principal Investigator

Takanari Hiroki  大分大学, 医学部, 助教 (70723253)

Research Collaborator Marcel van der Heyden  University Medical Center Utrecht, Department of Medical Physiology, Division of heart and Lungs, Associate Professor
Toon van Veen  University Medical Center Utrecht, Department of Medical Physiology, Division of heart and Lungs, Associate Professor
Vos Marc  University Medical Center Utrecht, Department of Medical Physiology, Division of heart and Lungs, Professor
Project Period (FY) 2014-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords心筋ギャップ結合 / Connexin43 / Connexin40 / カルモデュリン / CaMK-II / 脂質負荷 / コネキシン43 / コネキシン40 / カルモデュリン関連タンパクキナーゼ
Outline of Final Research Achievements

Gap junction in the heart tissue contributes to the intercellular communication between adjucent cardiomyocytes. Gap junction channel consists of connexin43 protein (Cx43) in ventricle. We examined the molecular mechanisms which control the expression and the subcellular distribution of Cx43 in the heart. Unfortunately, we could not find any apparent molecules from fetal gene program which could influence the expression of Cx43 expression. Calcium handling protein and protein kinase depends to it modified the distribution of Cx43 in the heart, which resulted in alteration of electrical conductance of the heart tissue. Cholesterol did not affect the expression of Cx43, while mRNA level of connexin40 protein was significantly decreased by cholesterol application. The result suggested the relation between lipid metabolism disorder and cardiac arrhythmias such as atrial fibrillation.

Report

(3 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2016 2015 2014 Other

All Int'l Joint Research (1 results) Journal Article (6 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 6 results) Presentation (5 results) (of which Invited: 1 results)

  • [Int'l Joint Research] University Medical Center Utrecht(オランダ)

    • Related Report
      2015 Annual Research Report
  • [Journal Article] Atrial fibrillation-mediated up-regulation of miR-30d regulates myocardial electrical remodeling of G-protein-gated K+ channel, IK,ACh.2016

    • Author(s)
      Morishima M, Iwata E, Nakada C, Tsukamoto Y, Takanari H, Minamoto S, Moriyama M, Ono K.
    • Journal Title

      Circulation Journal

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A New In Vitro Co-Culture Model Using Magnetic Force-Based Nanotechnology.2016

    • Author(s)
      Takanari H, Miwa K, Fu X, Nakai J, Ito A, Ino K, Honda H, Tonomura W, Konishi S, Opthof T, van der Heyden MA, Kodama I, Lee JK.
    • Journal Title

      Journal of Cellular Physiology

      Volume: 未定 Issue: 10 Pages: 1-8

    • DOI

      10.1002/jcp.25342

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Short- and long-term inhibition of cardiac inward-rectifier potassium channel current by an antiarrhythmic drug bepridil.2016

    • Author(s)
      Ma F, Takanari H, Masuda K, Morishima M, Ono K.
    • Journal Title

      Heart and Vessels

      Volume: 未定

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP感受性K+チャネル病の新規症候群ーCantu症候群2015

    • Author(s)
      平木洋子、高成広起
    • Journal Title

      脳と発達

      Volume: 97

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A systematic review and pooled analysis of CPR-associated cardiovascular and thoracic injuries.2015

    • Author(s)
      Okuda T, Takanari H, Shiotani S,
    • Journal Title

      Resuscitation

      Volume: 97 Pages: e3-e3

    • DOI

      10.1016/j.resuscitation.2014.12.035

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pericardial tear as a consequence of cardiopulmonary resuscitation (CPR) involving chest compression: a report of two postmortem cases of acute type A aortic dissection with hemopericardium.2015

    • Author(s)
      Okuda T, Takanari H, Shiotani S, Hayakawa H, Ohno Y, Fowler DR.
    • Journal Title

      Legal Medicine (Tokyo)

      Volume: 17 Issue: 3 Pages: 201-204

    • DOI

      10.1016/j.legalmed.2014.12.001

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Structure-based analysis of the function of Kir2.1 channel using a novel IK1 blocker PA-6: Interplay of PA-6, intracellular spermine2016

    • Author(s)
      Hiroki Takanari
    • Organizer
      第93回 日本生理学会大会 シンポジウム
    • Place of Presentation
      札幌コンベンションセンター、北海道、札幌市
    • Year and Date
      2016-03-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] 心筋Gap junctionのリモデリングと興奮伝導時間・Spiral-reentry・不整脈との関連2015

    • Author(s)
      高成広起
    • Organizer
      第10回 EP Expertsカンファレンス 教育講演
    • Place of Presentation
      TKP天神シティセンター、福岡県、福岡市
    • Year and Date
      2015-06-13
    • Related Report
      2015 Annual Research Report
    • Invited
  • [Presentation] Influence of high-cholesterol on arrhythmogenicity in mouse atrium2015

    • Author(s)
      高橋正起
    • Organizer
      第92回日本生理学会
    • Place of Presentation
      神戸国際会議場・展示場1号館(兵庫県神戸市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Research-status Report
  • [Presentation] 炎症と脂質負荷が心房細動発症に及ぼす影響2014

    • Author(s)
      高成広起
    • Organizer
      第24回日本循環薬理学会
    • Place of Presentation
      山形テルサ(山形県山形市)
    • Year and Date
      2014-12-05
    • Related Report
      2014 Research-status Report
  • [Presentation] カルモデュリン関連蛋白キナーゼ阻害が心筋興奮伝播に及ぼす影響:Connexin43発現分布の制御を介した 作用2014

    • Author(s)
      高成広起
    • Organizer
      第13回九州脳・高血圧・循環制御研究会
    • Place of Presentation
      ホテル日航福岡(福岡県福岡市)
    • Year and Date
      2014-07-19
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2017-05-10  

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