| Project/Area Number |
26860215
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Oita University |
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Principal Investigator |
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| Research Collaborator |
Marcel van der Heyden University Medical Center Utrecht, Department of Medical Physiology, Division of heart and Lungs, Associate Professor
Toon van Veen University Medical Center Utrecht, Department of Medical Physiology, Division of heart and Lungs, Associate Professor
Vos Marc University Medical Center Utrecht, Department of Medical Physiology, Division of heart and Lungs, Professor
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| Project Period (FY) |
2014-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 心筋ギャップ結合 / Connexin43 / Connexin40 / カルモデュリン / CaMK-II / 脂質負荷 / コネキシン43 / コネキシン40 / カルモデュリン関連タンパクキナーゼ |
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| Outline of Final Research Achievements |
Gap junction in the heart tissue contributes to the intercellular communication between adjucent cardiomyocytes. Gap junction channel consists of connexin43 protein (Cx43) in ventricle. We examined the molecular mechanisms which control the expression and the subcellular distribution of Cx43 in the heart. Unfortunately, we could not find any apparent molecules from fetal gene program which could influence the expression of Cx43 expression. Calcium handling protein and protein kinase depends to it modified the distribution of Cx43 in the heart, which resulted in alteration of electrical conductance of the heart tissue. Cholesterol did not affect the expression of Cx43, while mRNA level of connexin40 protein was significantly decreased by cholesterol application. The result suggested the relation between lipid metabolism disorder and cardiac arrhythmias such as atrial fibrillation.
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